Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.

• 資料種別: 博士論文
• タイトル: Osteogenic Matrix Cell Sheets Facilitate Osteogenesis in Irradiated Rat Bone.
• 著者・編者: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• 著者標目: Uchihara, Yoshinobu; Akahane, Manabu; Shimizu, Takamasa; Ueha, Tomoyuki; Morita, Yusuke; Nakasaki, Shintaro; Kura, Tomohiko; Tohma, Yasuaki; Kido, Akira; Kawate, Kenji; Tanaka, Yasuhito
• 出版事項: Hindawi Pub. Co.
• 出版年月日等: 2015
• 出版年（W3CDTF）: 2015
• 並列タイトル等: ラットにおいて骨形成細胞シートは放射線照射骨の骨形成能を促進させる
• タイトル（掲載誌）: BioMed research international
• 巻号年月日等（掲載誌）: 2015
• 掲載巻: 2015
• 掲載ページ: Article ID.629168-
• ISSN（掲載誌）: ISSN : 2314-6141
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-11-27
• 報告番号: 甲第642号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; Reconstruction of large bone defects after resection of malignant musculoskeletal tumors is a significant challenge in orthopedic surgery. Extracorporeal autogenous irradiated bone grafting is a treatment option for bone reconstruction. However, nonunion often occurs because the osteogenic capacity is lost by irradiation. In the present study, we established an autogenous irradiated bone graft model in the rat femur to assess whether osteogenic matrix cell sheets improve osteogenesis of the irradiated bone. Osteogenic matrix cell sheets were prepared from bone marrow-derived stromal cells and co-transplanted with irradiated bone. X-ray images at 4 weeks after transplantation showed bridging callus formation around the irradiated bone. Micro-computed tomography images at 12 weeks postoperatively showed abundant callus formation in the whole circumference of the irradiated bone. Histology showed bone union between the irradiated bone and host femur. Mechanical testing showed that the failure force at the irradiated bone site was significantly higher than in the control group. Our study indicates that osteogenic matrix cell sheet transplantation might be a powerful method to facilitate osteogenesis in irradiated bones, which may become a treatment option for reconstruction of bone defects after resection of malignant musculoskeletal tumors.; 博士（医学）・甲第642号・平成25年11月27日; Copyright © 2015 Yoshinobu Uchihara et al. This is an open access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.; identifier:BioMed research international Vol.2015 Article ID.629168; identifier:23146141; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3103; identifier:BioMed research international, 2015: Article ID.629168
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1155/2015/629168
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3103/1/01_%e7%94%b2642%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3103/2/02_%e7%94%b2642%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3103/3/03_%e7%94%b2642%e6%9c%ac%e6%96%87.pdf fulltext