Differential patterns of blood oxygenation in the prefrontal cortex between patients with methamphetamine-induced psychosis and schizophrenia.

• 資料種別: 博士論文
• タイトル: Differential patterns of blood oxygenation in the prefrontal cortex between patients with methamphetamine-induced psychosis and schizophrenia.
• 著者・編者: Yamamuro, Kazuhiko; Makinodan, Manabu; Kimoto, Sohei; Kishimoto, Naoko; Morimoto, Tsubasa; Toritsuka, Michihiro; Matsuoka, Kiwamu; Takebayashi, Yoshihiro; Takata, Tomoyo; Takahashi, Masato; Tanimura, Yoshinori; Nishihata, Yosuke; Matsuda, Yasuhiro; Ota, Toyosaku; Yoshino, Hiroki; Iida, Junzo; Kishimoto, Toshifumi
• 著者標目: Yamamuro, Kazuhiko; Makinodan, Manabu; Kimoto, Sohei; Kishimoto, Naoko; Morimoto, Tsubasa; Toritsuka, Michihiro; Matsuoka, Kiwamu; Takebayashi, Yoshihiro; Takata, Tomoyo; Takahashi, Masato; Tanimura, Yoshinori; Nishihata, Yosuke; Matsuda, Yasuhiro; Ota, Toyosaku; Yoshino, Hiroki; Iida, Junzo; Kishimoto, Toshifumi
• 出版事項: Nature Publishing Group
• 出版年月日等: 2015-06
• 出版年（W3CDTF）: 2015-06
• 並列タイトル等: 近赤外線スペクトロスコピィを用いた覚醒剤精神病と統合失調症の鑑別
• タイトル（掲載誌）: Scientific reports
• 巻号年月日等（掲載誌）: 5
• 掲載巻: 5
• 掲載ページ: Article No.12107-
• ISSN（掲載誌）: ISSN : 2045-2322
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2016-03-15
• 報告番号: 甲第645号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; Despite some slight differences in symptomatology, differential diagnosis of methamphetamine-induced psychosis (MAP) versus schizophrenia can be challenging because both disorders present a large overlap in their clinical symptoms. However, a recent study has shown that near-infrared spectroscopy (NIRS) performed during a cognitive task can be a powerful tool to differentiate between these two disorders. Here, we evaluated verbal fluency task performance during NIRS in 15 patients diagnosed with MAP and 19 with schizophrenia matched for age and sex. We used prefrontal probes and a 24-channel NIRS machine to measure the relative concentrations of oxyhaemoglobin every 0.1 s during the task. For each patient, the neurocognitive function and clinical psychopathology were evaluated using the Positive and Negative Symptom Scale (PANSS), and the Brief Assessment of Cognition in Schizophrenia (BACS). Oxyhaemoglobin changes in the prefrontal cortex were significantly higher in the MAP group compared to those in the schizophrenia group, particularly in the right dorsolateral prefrontal cortex. In contrast, we found no significant difference in PANSS and BACS scores. Our findings suggest that NIRS measurement could be applied to differentiate patients with MAP from those with schizophrenia, even in cases where clinical symptoms are similar.; 博士（医学）・甲第645号・平成28年3月15日; This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/; identifier:Scientific reports Vol.5 Article No.12107 (2015.06); identifier:20452322; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3177; identifier:Scientific reports, 5: Article No.12107
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1038/srep12107
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3177/1/01_%e7%94%b2645%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3177/2/02_%e7%94%b2645%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3177/3/03_%e7%94%b2645%e6%9c%ac%e6%96%87.pdf fulltext