Microglia-derived neuregulin expression in psychiatric disorders.

• 資料種別: 博士論文
• タイトル: Microglia-derived neuregulin expression in psychiatric disorders.
• 著者・編者: Ikawa, Daisuke; Makinodan, Manabu; Iwata, Keiko; Ohgidani, Masahiro; Kato, Takahiro A.; Yamashita, Yasunori; Yamamuro, Kazuhiko; Kimoto, Sohei; Toritsuka, Michihiro; Yamauchi, Takahira; Fukami, Shin-ichi; Yoshino, Hiroki; Okumura, Kazuki; Tanaka, Tatsuhide; Wanaka, Akio; Owada, Yuji; Tsujii, Masatsugu; Sugiyama, Toshiro; Tsuchiya, Kenji; Mori, Norio; Hashimoto, Ryota; Matsuzaki, Hideo; Kanba, Shigenobu; Kishimoto, Toshifumi
• 著者標目: Ikawa, Daisuke; Makinodan, Manabu; Iwata, Keiko; Ohgidani, Masahiro; Kato, Takahiro A.; Yamashita, Yasunori; Yamamuro, Kazuhiko; Kimoto, Sohei; Toritsuka, Michihiro; Yamauchi, Takahira; Fukami, Shin-ichi; Yoshino, Hiroki; Okumura, Kazuki; Tanaka, Tatsuhide; Wanaka, Akio; Owada, Yuji; Tsujii, Masatsugu; Sugiyama, Toshiro; Tsuchiya, Kenji; Mori, Norio; Hashimoto, Ryota; Matsuzaki, Hideo; Kanba, Shigenobu; Kishimoto, Toshifumi
• 出版事項: Elsevier
• 出版年月日等: 2017-03
• 出版年（W3CDTF）: 2017-03
• 並列タイトル等: 精神疾患におけるマイクログリア由来ニューレグリン発現
• タイトル（掲載誌）: Brain, behavior, and immunity
• 巻号年月日等（掲載誌）: 61
• 掲載巻: 61
• 掲載ページ: 375-385
• ISSN（掲載誌）: ISSN : 0889-1591
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2017-06-28
• 報告番号: 乙第1404号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Neuregulin; Microglia; Autism spectrum disorder; PBMCs; Cytokine
• 対象利用者: 一般
• 一般注記: type:Thesis; Several studies have revealed that neuregulins (NRGs) are involved in brain function and psychiatric disorders. While NRGs have been regarded as neuron- or astrocyte-derived molecules, our research has revealed that microglia also express NRGs, levels of which are markedly increased in activated microglia. Previous studies have indicated that microglia are activated in the brains of individuals with autism spectrum disorder (ASD). Therefore, we investigated microglial NRG mRNA expression in multiple lines of mice considered models of ASD. Intriguingly, microglial NRG expression significantly increased in BTBR and socially-isolated mice, while maternal immune activation (MIA) mice exhibited identical NRG expression to controls. Furthermore, we observed a positive correlation between NRG expression in microglia and peripheral blood mononuclear cells (PBMCs) in mice, suggesting that NRG expression in human PBMCs may mirror microglia-derived NRG expression in the human brain. To translate these findings for application in clinical psychiatry, we measured levels of NRG1 splice-variant expression in clinically available PBMCs of patients with ASD. Levels of NRG1 type III expression in PBMCs were positively correlated with impairments in social interaction in children with ASD (as assessed using the Autistic Diagnostic Interview-Revised test: ADI-R). These findings suggest that immune cell-derived NRGs may be implicated in the pathobiology of psychiatric disorders such as ASD.; 博士（医学）・乙第1404号・平成29年6月28日; Copyright © 2017 Elsevier Inc. All rights reserved.; identifier:Brain, behavior, and immunity Vol.61 p.375-385 (2017 Mar); identifier:08891591; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3350; identifier:Brain, behavior, and immunity, 61: 375-385
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.bbi.2017.01.003
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3350/1/01%e4%b9%991404%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3350/2/02%e4%b9%991404%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3350/3/03%e4%b9%991404%e6%9c%ac%e6%96%87.pdf fulltext