Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules.

• 資料種別: 博士論文
• タイトル: Factors that Differentiate between Endometriosis-associated Ovarian Cancer and Benign Ovarian Endometriosis with Mural Nodules.
• 著者・編者: Tanase, Yasuhito; Kawaguchi, Ryuji; Takahama, Junko; Kobayashi, Hiroshi
• 著者標目: Tanase, Yasuhito; Kawaguchi, Ryuji; Takahama, Junko; Kobayashi, Hiroshi
• 出版事項: Japanese Society for Magnetic Resonance in Medicine
• 出版年月日等: 2017-08-21
• 出版年（W3CDTF）: 2017-08-21
• 並列タイトル等: 子宮内膜症関連卵巣癌と隆起性病変を有する良性卵巣内膜症を鑑別する因子の検討
• タイトル（掲載誌）: Magnetic resonance in medical sciences
• 巻号年月日等（掲載誌）: 17 3
• 掲載巻: 17
• 掲載号: 3
• 掲載ページ: 231-237
• ISSN（掲載誌）: ISSN : 1347-3182
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2018-03-15
• 報告番号: 乙第1415号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: endometriosis; epithelial ovarian cancer; mural nodules; ultrasonography; diagnosis
• 対象利用者: 一般
• 一般注記: type:Thesis; PURPOSE: Mural nodules and papillary projections can be seen in benign ovarian endometriosis (OE) and malignant transformation of OE (endometriosis-associated ovarian cancer [EAOC]), which can pose a challenging diagnostic dilemma to clinicians. We identify the preoperative imaging characteristics helpful to the differential diagnosis between benign OE with mural nodules and EAOC. MATERIALS AND METHODS: This was a retrospective study of 82 patients who were diagnosed pathologically to have OE with mural nodules (n = 42) and malignant transformations of these tumors (n = 40) at the Nara Medical University Hospital from January 2008 to January 2015. All patients were assessed with contrast-enhanced magnetic resonance imaging (MRI) before surgery. Patient demographics, and clinical and pathologic features were analyzed to detect the significant differences between the two groups. RESULTS: Histological examinations of resected OE tissue specimens revealed that a majority (78.6%) of the mural nodular lesions were retracted blood clots. We found that the patients with malignant mural nodules, when compared to those with benign nodules, were older, had larger cyst diameters and larger mural nodule sizes, and were more likely to exhibit a taller than wider lesion. They were also more likely to present with various signal intensities on T1-weighted images (T1WI), high-signal intensity on T2-weighted images (T2WI), a lower proportion of shading on T2WI, and were more likely to show an anterior location of the cyst. In the multivariate logistic regression analysis, "Height" (>1.5 cm) and "Height-Width ratio (HWR)" (>0.9) of mural nodules, maximum diameter of the cyst (>7.9 cm), and age at diagnosis (>43 years) were independent predictors to distinguish EAOC from OE with mural nodules. CONCLUSION: The "Height" and "HWR" of the mural nodules in the cyst may yield a novel potential diagnostic factor for differentiating EAOC from benign OE with mural nodules.; 博士（医学）・乙第1415号・平成30年3月15日; ©2017 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License. https://creativecommons.org/licenses/by-nc-nd/4.0/.; identifier:Magnetic resonance in medical sciences Vol.17 No.3 p.231-237 (2018); identifier:13473182; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3431; identifier:Magnetic resonance in medical sciences, 17(3): 231-237
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2463/mrms.mp.2016-0149
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3431/1/01%e4%b9%991415%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3431/2/02%e4%b9%991415%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3431/3/03%e4%b9%991415%e6%9c%ac%e6%96%87.pdf fulltext