Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion.

• 資料種別: 博士論文
• タイトル: Superabsorbent Polymer Microspheres Prepared with Hypertonic Saline to Reduce Microsphere Expansion.
• 著者・編者: Sato, Takeshi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Morita, Kohei; Obayashi, Chiho; Hori, Shinich; Kaneko, Masaaki; Kijima, Ai; Kichikawa, Kimihiko
• 著者標目: Sato, Takeshi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Morita, Kohei; Obayashi, Chiho; Hori, Shinich; Kaneko, Masaaki; Kijima, Ai; Kichikawa, Kimihiko
• 出版事項: Springer Nature
• 出版年月日等: 2018-09
• 出版年（W3CDTF）: 2018-09
• 並列タイトル等: 超吸水性ポリマー球状塞栓物質の高張食塩水を用いた膨潤抑制法の開発
• タイトル（掲載誌）: Cardiovascular and interventional radiology
• 巻号年月日等（掲載誌）: 41 9
• 掲載巻: 41
• 掲載号: 9
• 掲載ページ: 1412-1418
• ISSN（掲載誌）: ISSN : 0174-1551
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2019-06-26
• 報告番号: 甲第709号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: TACE; Drug-eluting microsphere; Cisplatin
• 対象利用者: 一般
• 一般注記: type:Thesis; PURPOSE: To analyze size changes of superabsorbent polymer (SAP) microspheres with the reduced expansion technique, and to evaluate pharmacological advantages of transarterial chemoembolization using cisplatin-loaded SAP microspheres with the reduced expansion technique. MATERIALS AND METHODS: In an in vitro study, diluted contrast materials containing different concentrations of sodium ions were examined to expand SAP microspheres and determined the reduced expansion technique. Size distributions of cisplatin-loaded SAP microspheres were analyzed. In an in vivo study, TACE was performed using cisplatin-loaded SAP microspheres with the reduced expansion and control techniques in 18 VX2 rabbits. RESULTS: The degree of expansion was reduced to the greatest extent by using a mixture of non-ionic contrast material and 10% NaCl at a 4:1 ratio. The mean diameter of the reduced expansion of cisplatin-loaded SAP microspheres was 188.4 μm, while that of the control expansion was 404.9 μm. The plasma platinum concentrations of the reduced expansion group at 5 min after TACE were significantly higher than those of the control expansion group (2.19 ± 0.77 vs. 0.75 ± 0.08 μg/mL, P = .01). The tumor platinum concentrations of the reduced expansion group at 1 h were significantly higher than those of the control expansion group (10.76 ± 2.57 vs. 1.57 ± 0.14 μg/g, P = .044). CONCLUSION: The expanding level of SAP microspheres can be reduced by using hypertonic saline. Cisplatin-loaded SAP microspheres with the reduced expansion technique have the advantages of achieving higher cisplatin tissue concentration in TACE for liver tumors.; 博士（医学）・甲第709号・令和元年6月26日; © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018; This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular and interventional radiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00270-018-1990-4.; identifier:Cardiovascular and interventional radiology Vol.41 No.9 p.1412-1418 (2018 Sep); identifier:01741551; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3581; identifier:Cardiovascular and interventional radiology, 41(9): 1412-1418
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1007/s00270-018-1990-4
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3581/1/01%e7%94%b2709%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3581/2/02%e7%94%b2709%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3581/3/03%e7%94%b2709%e6%9c%ac%e6%96%87.pdf fulltext