Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer.

• 資料種別: 博士論文
• タイトル: Development of Repeatable Microcatheter Access Port for Intra-arterial Therapy of Liver Cancer.
• 著者・編者: Fukuoka, Yasushi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Sato, Takeshi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Sakaguchi, Hiroshi; Kichikawa, Kimihiko
• 著者標目: Fukuoka, Yasushi; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Sato, Takeshi; Masada, Tetsuya; Tatsumoto, Shota; Marugami, Nagaaki; Sakaguchi, Hiroshi; Kichikawa, Kimihiko
• 出版事項: Springer Nature
• 出版年月日等: 2019-02
• 出版年（W3CDTF）: 2019-02
• 並列タイトル等: 肝癌に対する経動脈的治療におけるマイクロカテーテル挿入可能ポー トの開発
• タイトル（掲載誌）: Cardiovascular and interventional radiology
• 巻号年月日等（掲載誌）: 42 2
• 掲載巻: 42
• 掲載号: 2
• 掲載ページ: 298-303
• ISSN（掲載誌）: ISSN : 0174-1551
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2019-06-26
• 報告番号: 甲第710号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Transarterial chemoembolization; Hepatic arterial infusion chemotherapy; Implantable port
• 対象利用者: 一般
• 一般注記: type:Thesis; PURPOSE: To develop an implantable port in which a microcatheter can be inserted for a combination therapy of repeated transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) for advanced liver cancer. MATERIALS AND METHODS: The design of a currently used implantable port was modified. A funnel part was constructed in the port. The septum was punctured by a 20-gauge indwelling needle, and 2.0-Fr non-tapered microcatheter was inserted into the port. In the in vitro studies, the advance of a microcatheter out of the funnel part was evaluated via seven different septum puncture sites. A 5-Fr indwelling catheter connected to the port was placed in a vascular model, and a microcatheter catheterization was evaluated. In an in vivo study, the port-catheter system was implanted in the hepatic artery in a pig. A microcatheter was percutaneously inserted through the port into the hepatic arterial branches, and embolization was performed. RESULTS: In the in vitro studies, the microcatheter was smoothly advanced out of the port and catheterizations into the hepatic arteries were successful via all septum puncture sites. In the in vivo study, repeated selective embolization through the port was successfully conducted on 7, 14 and 21 days after the implantation. CONCLUSION: The developed implantable port can be used for repeated catheter insertion into the hepatic artery. The combination of repeated TACE and HAIC could be possible using this device.; 博士（医学）・甲第710号・令和元年6月26日; © Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018; This is a post-peer-review, pre-copyedit version of an article published in Cardiovascular and interventional radiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00270-018-2111-0.; identifier:Cardiovascular and interventional radiology Vol.42 No.2 p.298-303 (2019 Feb); identifier:01741551; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3582; identifier:Cardiovascular and interventional radiology, 42(2): 298-303
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1007/s00270-018-2111-0
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3582/1/01%e7%94%b2710%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3582/2/02%e7%94%b2710%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3582/6/03%e7%94%b2710%e6%9c%ac%e6%96%87.pdf fulltext