Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice.

• 資料種別: 博士論文
• タイトル: Vestibular Compensation after Vestibular Dysfunction Induced by Arsanilic Acid in Mice.
• 著者・編者: Ito, Taeko; Tatsumi, Kouko; Takimoto, Yasumitsu; Nishimura, Tadashi; Imai, Takao; Yamanaka, Toshiaki; Takeda, Noriaki; Wanaka, Akio; Kitahara, Tadashi
• 著者標目: Ito, Taeko; Tatsumi, Kouko; Takimoto, Yasumitsu; Nishimura, Tadashi; Imai, Takao; Yamanaka, Toshiaki; Takeda, Noriaki; Wanaka, Akio; Kitahara, Tadashi
• 出版事項: MDPI
• 出版年月日等: 2019-11-18
• 出版年（W3CDTF）: 2019-11-18
• 並列タイトル等: アルサニル酸を用いたマウス内耳破壊後の前庭代償過程
• タイトル（掲載誌）: Brain sciences
• 巻号年月日等（掲載誌）: 9 11
• 掲載巻: 9
• 掲載号: 11
• 掲載ページ: Article No.329-
• ISSN（掲載誌）: ISSN : 2076-3425
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-03-16
• 報告番号: 甲第742号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: mouse; labyrinthectomy; p-arsanilic acid; c-Fos; Arc; Zif268; vestibular nucleus; head deviation; nystagmus; vestibular compensation
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; type:Thesis; When vestibular function is lost, vestibular compensation works for the reacquisition of body balance. For the study of vestibular dysfunction and vestibular compensation, surgical or chemical labyrinthectomy has been performed in various animal species. In the present study, we performed chemical labyrinthectomy using arsanilic acid in mice and investigated the time course of vestibular compensation through behavioral observations and histological studies. The surgical procedures required only paracentesis and storage of 50 µL of p-arsanilic acid sodium salt solution in the tympanic cavity for 5 min. From behavioral observations, vestibular functions were worst at 2 days and recovered by 7 days after surgery. Spontaneous nystagmus appeared at 1 day after surgery with arsanilic acid and disappeared by 2 days. Histological studies revealed specific damage to the vestibular endorgans. In the ipsilateral spinal vestibular nucleus, the medial vestibular nucleus, and the contralateral prepositus hypoglossal nucleus, a substantial number of c-Fos-immunoreactive cells appeared by 1 day after surgery with arsanilic acid, with a maximum increase in number by 2 days and complete disappearance by 7 days. Taken together, these findings indicate that chemical labyrinthectomy with arsanilic acid and the subsequent observation of vestibular compensation is a useful strategy for elucidation of the molecular mechanisms underlying vestibular pathophysiologies.; 博士（医学）・甲第742号・令和2年3月16日; © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).; identifier:Brain sciences Vol.9 No.11 Article No.329 (2019 Nov); identifier:20763425; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3736; identifier:Brain sciences, 9(11): Article No.329
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3736/1/01%e7%94%b2742%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3736/2/02%e7%94%b2742%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3736/3/03%e7%94%b2742%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3390/brainsci9110329; https://doi.org/10.3390/brainsci9110329
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU