Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.

• 資料種別: 博士論文
• タイトル: Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.
• 著者・編者: Akasaka, Juria; Naruse, Katsuhiko; Sado, Toshiyuki; Uchiyama, Tomoko; Makino, Mai; Yamauchi, Akiyo; Ota, Hiroyo; Sakuramoto-Tsuchida, Sumiyo; Itaya-Hironaka, Asako; Takasawa, Shin; Kobayashi, Hiroshi
• 著者標目: Akasaka, Juria; Naruse, Katsuhiko; Sado, Toshiyuki; Uchiyama, Tomoko; Makino, Mai; Yamauchi, Akiyo; Ota, Hiroyo; Sakuramoto-Tsuchida, Sumiyo; Itaya-Hironaka, Asako; Takasawa, Shin; Kobayashi, Hiroshi
• 出版事項: MDPI
• 出版年月日等: 2019-11
• 出版年（W3CDTF）: 2019-11
• 並列タイトル等: 妊娠高血圧症候群におけるRAGEの関与
• タイトル（掲載誌）: International journal of molecular sciences
• 巻号年月日等（掲載誌）: 20 21
• 掲載巻: 20
• 掲載号: 21
• 掲載ページ: Article No.5462-
• ISSN（掲載誌）: ISSN : 1422-0067
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-03-16
• 報告番号: 乙第1451号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: hypertensive disorders of pregnancy; RAGE; AGE; adipocyte; IL-6; CCL2; LPS
• 対象利用者: 一般
• 一般注記: type:Thesis; Preeclampsia/hypertensive disorders of pregnancy (PE/HDP) is a serious and potentially life-threatening disease. Recently, PE/HDP has been considered to cause adipose tissue inflammation, but the detailed mechanism remains unknown. We exposed human primary cultured adipocytes with serum from PE/HDP and healthy controls for 24 h, and analyzed mRNA expression of several adipokines, cytokines, and ligands of the receptor for advanced glycation endproducts (RAGE). We found that the mRNA levels of interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), high mobility group box 1 (HMGB1), and RAGE were significantly increased by the addition of PE/HDP serum. Among RAGE ligands, advanced glycation endproducts (AGE) and HMGB1 increased mRNA levels of IL-6 and CCL2 in SW872 human adipocytes and mouse 3T3-L1 cells. The introduction of small interfering RNA for RAGE (siRAGE) into SW872 cells abolished the AGE- and HMGB1-induced up-regulation of IL-6 and CCL2. In addition, lipopolysaccharide (LPS), a ligand of RAGE, increased the expression of IL-6 and CCL2 and siRAGE attenuated the LPS-induced expression of IL-6 and CCL2. These results strongly suggest that the elevated AGE, HMGB1, and LPS in pregnant women up-regulate the expression of IL-6 and CCL2 via the RAGE system, leading to systemic inflammation such as PE/HDP.; 博士（医学）・乙第1451号・令和2年3月16日; © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).; identifier:International journal of molecular sciences Vol.20 No.21 Article No.5462 (2019 Nov); identifier:14220067; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3741; identifier:International journal of molecular sciences, 20(21): Article No.5462
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3390/ijms20215462
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3741/1/01%e4%b9%991451%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3741/2/02%e4%b9%991451%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3741/3/03%e4%b9%991451%e6%9c%ac%e6%96%87.pdf fulltext