Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder.

• 資料種別: 博士論文
• タイトル: Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder.
• 著者・編者: Fukui, Shinji; Aoki, Katsuya; Morizawa, Yosuke; Miyake, Makito; Fujimoto, Kiyohide
• 著者標目: Fukui, Shinji; Aoki, Katsuya; Morizawa, Yosuke; Miyake, Makito; Fujimoto, Kiyohide
• 出版事項: Elsevier
• 出版年月日等: 2017-05
• 出版年（W3CDTF）: 2017-05
• 並列タイトル等: 尿中Nerve Growth Factorは、過活動膀胱症状を呈する患児の治療効果の予測因子になる
• タイトル（掲載誌）: Urology
• 巻号年月日等（掲載誌）: 103
• 掲載巻: 103
• 掲載ページ: 214-217
• ISSN（掲載誌）: ISSN : 0090-4295
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2020-03-16
• 報告番号: 乙第1454号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; Objective: To assess urinary nerve growth factor (NGF) in children with overactive bladder (OAB) and to investigate the relationship between urinary NGF/creatinine (Cr) levels and OAB. Patients and methods: Thirty-five children (27 boys and 8 girls) with OAB and 11 children (6 boys and 5 girls) without OAB or any other urinary symptoms, who served as controls, were included in this study. Urinary NGF levels were measured using enzyme-linked immunosorbent assay. The total urinary NGF levels were adjusted with the concentration of urinary creatinine (NGF/Cr level). Refractory OAB was defined as little improvement in OAB symptoms despite at least 3 months of urotherapy and anticholinergic agent treatment. Urinary NGF/Cr was compared between the children with OAB and the controls. The relationship between urinary NGF/Cr and treatment outcomes was also evaluated. Results: Urinary NGF/Cr was significantly higher in the children with OAB when compared with those in the control group (0.65 ± 0.82 vs 0.11 ± 0.09, P = .0007). Improvement of OAB symptoms was observed in 26 out of 35 children (74%). The remaining 9 children showed refractory OAB symptoms (the refractory group). Urinary NGF/Cr was significantly higher in the refractory group than in the improved group (1.28 ± 1.34 vs 0.44 ± 0.39, P = .027). Conclusion: Urinary NGF/Cr was significantly higher in the children with OAB than in the controls, and was significantly higher in the refractory group than in the improved group. Urinary NGF/Cr could not only be a potential biomarker for children with OAB, but also a predictor of therapeutic efficacy in children with OAB.; 博士（医学）・乙第1454号・令和2年3月16日; Copyright © 2017 Elsevier Inc. All rights reserved.; identifier:Urology Vol.103 p.214-217 (2017 May); identifier:00904295; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3744; identifier:Urology, 103: 214-217
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.urology.2017.01.021
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3744/1/01%e4%b9%991454%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3744/2/02%e4%b9%991454%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

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