並列タイトル等脊椎手術におけるMEPでの定電圧刺激を用いた経頭蓋刺激は、定電流刺激よりAnesthetic fadeの影響を受けにくい
一般注記type:Thesis
Study design: A prospective, within-subject study was conducted. Objective: We aimed to compare the influence of anesthetic fade under maximum stimulation conditions between constant-current and constant-voltage stimulation techniques. Summary of background data: The monitoring of muscle-evoked potentials after electrical stimulation to the brain [Br(E)-MSEP)] is useful for assessing the integrity of spinal cord motor tracts during major spine surgery. Nonetheless, Br(E)-MSEP responses are known to deteriorate over the duration of surgeries performed under general anesthesia. This phenomenon is known as anesthetic fade. Methods: We recruited 117 patients undergoing various spinal surgeries from the cervical to the lumbar level. We excluded 29 cases with insufficient data. The decrease rate of the Br(E)-MSEP amplitude for each muscle was examined. Br(E)-MSEP monitoring with constant-current and constant-voltage stimulations at the C3 and C4 electrode positions was applied. Compound muscle action potentials (CMAPs) were bilaterally recorded from the abductor pollicis brevis, deltoid, abductor hallucis, tibialis anterior, gastrocnemius, and quadriceps muscles. We defined the decrease rate as follows: (initial CMAPs-final CMAPs)/initial CMAPs × 100. Differences in the decrease rate were evaluated between stimulators, limbs (upper vs. lower), and operative time group (lowest quartile vs. highest quartile). Results: The overall decrease rate (across all muscles) increased as the operative time increased, and the rate was higher in the lower limbs than in the upper limbs. In addition, the overall decrease rate was lower with constant-voltage stimulation than with constant-current stimulation. Furthermore, the decrease rate for constant-current stimulation was significantly higher than that for constant-voltage stimulation, regardless of the operative time. Conclusion: The CMAP waveform with constant-voltage stimulation is less susceptible to anesthetic fade than that with constant-current stimulation, even during long surgeries. Level of evidence: 3.
博士（医学）・甲第752号・令和2年9月30日
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This is a non-final version of an article published in final form in Spine Vol.44 No.21 p.1492-1498 (2019 Nov) (http://dx.doi.org/10.1097/BRS.0000000000003166).
identifier:Spine Vol.44 No.21 p.1492-1498 (2019 Nov)
identifier:03622436
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3776
identifier:Spine, 44(21): 1492-1498
関連情報（DOI）10.1097/BRS.0000000000003166
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
提供元機関・データベース奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU