Prevalence of Helicobacter pylori among residents and their environments in the Nara prefecture, Japan.

• 資料種別: 博士論文
• タイトル: Prevalence of Helicobacter pylori among residents and their environments in the Nara prefecture, Japan.
• 著者・編者: Horiuchi, Saori; Nakano, Ryuichi; Nakano, Akiyo; Hishiya, Naokuni; Uno, Kenji; Suzuki, Yuki; Kakuta, Naoki; Kakuta, Risako; Tsubaki, Kohsuke; Jojima, Noriko; Yano, Hisakazu
• 著者標目: Horiuchi, Saori; Nakano, Ryuichi; Nakano, Akiyo; Hishiya, Naokuni; Uno, Kenji; Suzuki, Yuki; Kakuta, Naoki; Kakuta, Risako; Tsubaki, Kohsuke; Jojima, Noriko; Yano, Hisakazu
• 出版事項: Elsevier
• 出版年月日等: 2021-02
• 出版年（W3CDTF）: 2021-02
• 並列タイトル等: 奈良県の地域住民と生活環境におけるピロリ菌の蔓延実態
• タイトル（掲載誌）: Journal of infection and public health
• 巻号年月日等（掲載誌）: 14 2
• 掲載巻: 14
• 掲載号: 2
• 掲載ページ: 271-275
• ISSN（掲載誌）: ISSN : 1876-0341
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2021-03-15
• 報告番号: 甲第774号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Helicobacter pylori; Infection source; Recurrent infection; cagA
• 対象利用者: 一般
• 一般注記: type:Thesis; Background: Chronic infection with Helicobacter pylori, specifically cagA-positive strains, is associated with gastric cancer. Thus, measures to prevent H. pylori infection are required. This study was conducted to clarify the prevalence of H. pylori in the community to identify the infection source and comprehensively assess the risk of H. pylori infection. Methods: We collected 90 human faecal samples and 73 environmental samples (water, vegetable, and animal faecal samples) from the residents in an area with a high incidence of gastric cancer in Japan. Polymerase chain reaction assay was performed to detect the glmM housekeeping gene and the cagA virulence gene of H. pylori. A questionnaire survey was conducted, and the responses were analyzed statistically. Results: The glmM gene was detected in 18 of 90 (20%) faecal samples obtained from residents; among them, the cagA gene was detected in 33.3% (6/18), and in all who had undergone eradication therapy. H. pylori was not detected in environmental samples. However, contact with dogs (OR 3.89, 95% CI 1.15-13.15, P < 0.05) was associated with higher odds for glmM gene positivity in the questionnaire survey. Conclusions: The prevalence of H. pylori and cagA-positive strains among the residents was low. However, the study results suggest a correlation between recurrent infection and cagA-positive H. pylori strains. Although H. pylori genes were not detected in living environments, an association between contact with dogs and a glmM positive status was revealed. Further investigations targeting community-dwelling healthy people and their living environments would be required for H. pylori infection control.; 博士（医学）・甲第774号・令和3年3月15日; © 2020 The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).; identifier:Journal of infection and public health Vol.14 No.2 p.271-275 (2021 Feb); identifier:18760341; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3898; identifier:Journal of infection and public health, 14(2): 271-275
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.jiph.2020.11.018
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3898/1/01%e7%94%b2774%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3898/2/02%e7%94%b2774%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3898/3/03%e7%94%b2774%e6%9c%ac%e6%96%87.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3898/4/04%e7%94%b2774Suppl..pdf fulltext