A Rat Model of Frozen Shoulder Demonstrating the Effect of Transcatheter Arterial Embolization on Angiography, Histopathology, and Physical Activity.

• 資料種別: 博士論文
• タイトル: A Rat Model of Frozen Shoulder Demonstrating the Effect of Transcatheter Arterial Embolization on Angiography, Histopathology, and Physical Activity.
• 著者・編者: Taguchi, Hidehiko; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Minamiguchi, Kiyoyuki; Taiji, Ryosuke; Takayama, Katsutoshi; Takeda, Maiko; Hatakeyama, Kinta; Inoue, Takashi; Ohbayashi, Chiho; Kichikawa, Kimihiko
• 著者標目: Taguchi, Hidehiko; Tanaka, Toshihiro; Nishiofuku, Hideyuki; Fukuoka, Yasushi; Minamiguchi, Kiyoyuki; Taiji, Ryosuke; Takayama, Katsutoshi; Takeda, Maiko; Hatakeyama, Kinta; Inoue, Takashi; Ohbayashi, Chiho; Kichikawa, Kimihiko
• 出版事項: Elsevier
• 出版年月日等: 2021-03
• 出版年（W3CDTF）: 2021-03
• 並列タイトル等: ラット凍結肩モデルを用いた経カテーテル的動脈塞栓術の効果に関する検討
• タイトル（掲載誌）: Journal of vascular and interventional radiology
• 巻号年月日等（掲載誌）: 32 3
• 掲載巻: 32
• 掲載号: 3
• 掲載ページ: 376-383
• ISSN（掲載誌）: ISSN : 1051-0443
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2021-03-15
• 報告番号: 甲第789号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; Purpose: To assess the angiographic findings and the effects of transcatheter arterial embolization on physical activity and histopathology using a frozen shoulder rat model. Materials and methods: First, the angiographic and histopathologic findings of rats in which the shoulder was immobilized with molding plaster for 6 weeks (n = 4) were compared to control rats with normal non-immobilized shoulders (n = 4). Next, a total of 16 frozen shoulder rats were divided into 2 groups. In the transcatheter arterial embolization group (n = 8), imipenem/cilastatin was injected into the left thoracoacromial artery. The changes of physical activity before and after procedures were evaluated and compared with a saline-injected control group (n = 8). Histopathologic findings were also compared between the 2 groups. Results: Angiography revealed abnormal shoulder staining in all of the rats with a frozen shoulder. On histopathology, the numbers of microvessels and mononuclear inflammatory cells in the synovial membrane of the joint capsule were significantly higher compared with the control rats (both P = .03). In the transcatheter arterial embolization group, the running distance and speed were improved (P = .03 and P = .01, respectively), whereas there were no significant differences in the control group. The number of microvessels and mononuclear inflammatory cells in the transcatheter arterial embolization group were significantly lower than the control group (P = .002 and P = .001, respectively). Conclusions: The rat frozen shoulder model revealed the development of neovascularization. Transcatheter arterial embolization decreased the number of blood vessels and inflammatory changes in the frozen shoulder and increased the moving distance and speed of the rats.; 博士（医学）・甲第789号・令和3年3月15日; Copyright © 2020 SIR(Society of Interventional Radiology). Published by Elsevier Inc. All rights reserved.; identifier:Journal of vascular and interventional radiology Vol.32 No.3 p.376-383 (2021 Mar); identifier:10510443; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3913; identifier:Journal of vascular and interventional radiology, 32(3): 376-383
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.017
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3913/1/01%e7%94%b2789%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3913/2/02%e7%94%b2789%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/3913/3/03%e7%94%b2789%e6%9c%ac%e6%96%87.pdf fulltext