Fractal dimension in CT low attenuation areas is predictive of long-term oxygen therapy initiation in COPD patients: Results from two observational cohort studies.

• 資料種別: 博士論文
• タイトル: Fractal dimension in CT low attenuation areas is predictive of long-term oxygen therapy initiation in COPD patients: Results from two observational cohort studies.
• 著者・編者: Ibaraki, Takahiro; Tomoda, Koich; Fujioka, Nobuhiro; Sakaguchi, Kazuhiro; Fujita, Yukio; Yamamoto, Yoshifumi; Hontsu, Shigeto; Yamauchi, Motoo; Yoshikawa, Masanori; Tanabe, Naoya; Tanimura, Kazuya; Sato, Susumu; Saeki, Keigo; Muro, Shigeo
• 著者標目: Ibaraki, Takahiro; Tomoda, Koich; Fujioka, Nobuhiro; Sakaguchi, Kazuhiro; Fujita, Yukio; Yamamoto, Yoshifumi; Hontsu, Shigeto; Yamauchi, Motoo; Yoshikawa, Masanori; Tanabe, Naoya; Tanimura, Kazuya; Sato, Susumu; Saeki, Keigo; Muro, Shigeo
• 出版事項: Elsevier
• 出版年月日等: 2022-01
• 出版年（W3CDTF）: 2022-01
• 並列タイトル等: CTにおける低吸収領域のフラクタル次元は、COPD患者の長期酸素療法開始を予測する : 2つのコホート研究結果より
• タイトル（掲載誌）: Respiratory investigation
• 巻号年月日等（掲載誌）: 60 1
• 掲載巻: 60
• 掲載号: 1
• 掲載ページ: 137-145
• ISSN（掲載誌）: ISSN : 2212-5345
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2022-03-15
• 報告番号: 甲第824号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: COPD; Computed tomography; Fractal property; Long term oxygen therapy (LTOT); Pulmonary function test
• 対象利用者: 一般
• 一般注記: type:Thesis; Background: Some chronic obstructive pulmonary disease (COPD) patients develop hypoxemia with disease progression, with some even requiring long-term oxygen therapy (LTOT). Lung function, especially diffusing capacity, and the annual decline in PaO₂, are reported to be predictive factors of chronic respiratory failure. However, the association between lung morphometry evaluated using computed tomography (CT) images and LTOT initiation is unknown. Methods: We retrospectively evaluated the relationship between clinical indices, including pulmonary function, body mass index (BMI), and CT parameters, at baseline and LTOT initiation in two prospective COPD cohorts. In the Nara Medical University cohort (n = 76), the low attenuation area (LAA) and its fractal dimension (fractal D) were adapted as the indices for parenchymal destruction in CT images. The association between these CT measurements and LTOT initiation was replicated in the Kyoto University cohort (n = 130). Results: In the Nara Medical University cohort, lower BMI (hazard ratio [HR]:0.70, p = 0.006), lower % diffusing capacity (%DLCO) (HR: 0.92, p = 0.006), lower %DLCO/VA (HR, 0.90, p = 0.008), higher RV/TLC (HR, 1.26, p = 0.012), higher LAA% (HR: 1.18, p = 0.001), and lower fractal D (HR: 3.27 × 10⁻⁸, p < 0.001) were associated with LTOT initiation. Multivariate analysis in the Kyoto University cohort confirmed that lower %DLCO and lower fractal D were independently associated with LTOT initiation, whereas LAA% was not. Conclusion: Fractal D, which is the index for morphometric complexity of LAA in CT analysis, is predictive of LTOT initiation in COPD patients.; 博士（医学）・甲第824号・令和4年3月15日; © 2021 The Authors Published by Elsevier B.V. on behalf of The Japanese Respiratory Society.; identifier:Respiratory investigation Vol.60 No.1 p.137-145 (2022 Jan); identifier:22125345; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4007; identifier:Respiratory investigation, 60(1): 137-145
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4007/1/01%e7%94%b2824%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4007/2/02%e7%94%b2824%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4007/3/03%e7%94%b2824%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.resinv.2021.09.001
• 掲載誌（NCID）: AA12579673; https://ci.nii.ac.jp/ncid/AA12579673
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU