The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy

• 資料種別: 博士論文
• タイトル: The Comparison of Three Predictive Indexes to Discriminate Malignant Ovarian Tumors from Benign Ovarian Endometrioma: The Characteristics and Efficacy
• 著者・編者: Yamanaka, Shoichiro; Kawahara, Naoki; Kawaguchi, Ryuji; Waki, Keita; Maehana, Tomoka; Fukui, Yosuke; Miyake, Ryuta; Yamada, Yuki; Kobayashi, Hiroshi; Kimura, Fuminori
• 著者標目: Yamanaka, Shoichiro; Kawahara, Naoki; Kawaguchi, Ryuji; Waki, Keita; Maehana, Tomoka; Fukui, Yosuke; Miyake, Ryuta; Yamada, Yuki; Kobayashi, Hiroshi; Kimura, Fuminori
• 出版事項: MDPI
• 出版年月日等: 2022-05-12
• 出版年（W3CDTF）: 2022-05-12
• 並列タイトル等: 卵巣悪性腫瘍と良性内膜症性嚢胞の鑑別における各予測インデックスの特徴と有用性の比較
• タイトル（掲載誌）: Diagnostics
• 巻号年月日等（掲載誌）: 12 5
• 掲載巻: 12
• 掲載号: 5
• 掲載ページ: Article No.1212-
• ISSN（掲載誌）: ISSN : 2075-4418
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2023-03-15
• 報告番号: 甲第875号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: ovarian endometrioma; endometriosis associated ovarian cancer; malignant ovarian tumor; borderline ovarian tumor; CPH index; ROMA index; R2 predictive index
• 対象利用者: 一般
• 一般注記: type:Thesis; This study aimed to evaluate the prediction efficacy of malignant transformation of ovarian endometrioma (OE) using the Copenhagen Index (CPH-I), the risk of ovarian malignancy algorithm (ROMA), and the R2 predictive index. This retrospective study was conducted at the Department of Gynecology, Nara Medical University Hospital, from January 2008 to July 2021. A total of 171 patients were included in the study. In the current study, cases were divided into three cohorts: pre-menopausal, post-menopausal, and a combined cohort. Patients with benign ovarian tumor mainly received laparoscopic surgery, and patients with suspected malignant tumors underwent laparotomy. Information from a review chart of the patients’ medical records was collected. In the combined cohort, a multivariate analysis confirmed that the ROMA index, the R2 predictive index, and tumor laterality were extracted as independent factors for predicting malignant tumors (hazard ratio (HR): 222.14, 95% confidence interval (CI): 22.27–2215.50, p < 0.001; HR: 9.80, 95% CI: 2.90–33.13, p < 0.001; HR: 0.15, 95% CI: 0.03–0.75, p = 0.021, respectively). In the pre-menopausal cohort, a multivariate analysis confirmed that the CPH index and the R2 predictive index were extracted as independent factors for predicting malignant tumors (HR: 6.45, 95% CI: 1.47–28.22, p = 0.013; HR: 31.19, 95% CI: 8.48–114.74, p < 0.001, respectively). Moreover, the R2 predictive index was only extracted as an independent factor for predicting borderline tumors (HR: 45.00, 95% CI: 7.43–272.52, p < 0.001) in the combined cohort. In pre-menopausal cases or borderline cases, the R2 predictive index is useful; while, in post-menopausal cases, the ROMA index is better than the other indexes.; 博士（医学）・甲第875号・令和5年3月15日; © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).; identifier:Diagnostics Vol.12 No.5 Article No.1212 (2022 May); identifier:20754418; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4107; identifier:Diagnostics, 12(5): Article No.1212
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3390/diagnostics12051212
• 関連情報（NCID）: BB0676002X; https://ci.nii.ac.jp/ncid/BB0676002X
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4107/1/01%e7%94%b2875%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4107/2/02%e7%94%b2875%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4107/6/03%e7%94%b2875%e6%9c%ac%e6%96%87.pdf fulltext