並列タイトル等ラット肝腫瘍モデルにおける化学療法の早期効果判定に有用なダイナミック造影超音波のパラメータについて
タイトル(掲載誌)Journal of clinical imaging science
一般注記type:Thesis
Objectives: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic
contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether
the parameter could correlate with the early response to irinotecan in a rat liver tumor model.
Material and Methods: Twenty rats with tumors were evaluated (control: Saline, n = 6; treatment: Irinotecan,
n = 14) regarding four parameters from TIC: Peak intensity (PI), k value, slope (PI × k), and time to peak (TTP).
Relative changes in maximum tumor diameter between day 0 and 10, and parameters in the first 3 days were
evaluated. The Mann-Whitney U-test was used to compare differences in tumor size and other parameters.
Pearson’s correlation coefficients (r) between tumor size and parameters in the control group were calculated.
In the treatment group, relative changes of parameters in the first 3 days were compared between responder and
non-responder (<20% and ≥20% increase in size on day 10, respectively).
Results: PI, k value, PI × k, and TTP significantly correlated with tumor growth (r = 0.513, 0.911, 0.665, and 0.741,
respectively). The mean RC in k value among responders (n = 6) was significantly lower than non-responders
(n = 8) (mean k value, 4.96 vs. 72.5; P = 0.003).
Conclusion: Parameters of DCE-US could be a useful parameter for identifying early response to irinotecan.
博士(医学)・甲第879号・令和5年3月15日
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identifier:Journal of clinical imaging science Vol.11 Article No.15 (2021 Mar)
identifier:21567514
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4111
identifier:Journal of clinical imaging science, 11: Article No.15
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
提供元機関・データベース奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU