Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model

• 資料種別: 博士論文
• タイトル: Useful Parameters in Dynamic Contrast-enhanced Ultrasonography for Identifying Early Response to Chemotherapy in a Rat Liver Tumor Model
• 著者・編者: Taiji, Ryosuke; Nishiofuku, Hideyuki; Tanaka, Toshihiro; Minamiguchi, Kiyoyuki; Fukuoka, Yasushi; Saito, Natsuhiko; Taguchi, Hidehiko; Matsumoto, Takeshi; Marugami, Nagaaki; Hirai, Toshiko; Kichikawa, Kimihiko
• 著者標目: Taiji, Ryosuke; Nishiofuku, Hideyuki; Tanaka, Toshihiro; Minamiguchi, Kiyoyuki; Fukuoka, Yasushi; Saito, Natsuhiko; Taguchi, Hidehiko; Matsumoto, Takeshi; Marugami, Nagaaki; Hirai, Toshiko; Kichikawa, Kimihiko
• 出版事項: Scientific Scholar
• 出版年月日等: 2021-03-15
• 出版年（W3CDTF）: 2021-03-15
• 並列タイトル等: ラット肝腫瘍モデルにおける化学療法の早期効果判定に有用なダイナミック造影超音波のパラメータについて
• タイトル（掲載誌）: Journal of clinical imaging science
• 巻号年月日等（掲載誌）: 11
• 掲載巻: 11
• 掲載ページ: Article No.15-
• ISSN（掲載誌）: ISSN : 2156-7514
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2023-03-15
• 報告番号: 甲第879号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Ultrasonography; Colon cancer; Rats; Biomarkers; Irinotecan; Contrast media
• 対象利用者: 一般
• 一般注記: type:Thesis; Objectives: The objective of the study is to determine a parameter on the time-intensity curve (TIC) of dynamic contrast-enhanced ultrasonography (DCE-US) that best correlates with tumor growth and to evaluate whether the parameter could correlate with the early response to irinotecan in a rat liver tumor model. Material and Methods: Twenty rats with tumors were evaluated (control: Saline, n = 6; treatment: Irinotecan, n = 14) regarding four parameters from TIC: Peak intensity (PI), k value, slope (PI × k), and time to peak (TTP). Relative changes in maximum tumor diameter between day 0 and 10, and parameters in the first 3 days were evaluated. The Mann-Whitney U-test was used to compare differences in tumor size and other parameters. Pearson’s correlation coefficients (r) between tumor size and parameters in the control group were calculated. In the treatment group, relative changes of parameters in the first 3 days were compared between responder and non-responder (<20% and ≥20% increase in size on day 10, respectively). Results: PI, k value, PI × k, and TTP significantly correlated with tumor growth (r = 0.513, 0.911, 0.665, and 0.741, respectively). The mean RC in k value among responders (n = 6) was significantly lower than non-responders (n = 8) (mean k value, 4.96 vs. 72.5; P = 0.003). Conclusion: Parameters of DCE-US could be a useful parameter for identifying early response to irinotecan.; 博士（医学）・甲第879号・令和5年3月15日; ©2021 Published by Scientific Scholar on behalf of Journal of Clinical Imaging Science This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.; identifier:Journal of clinical imaging science Vol.11 Article No.15 (2021 Mar); identifier:21567514; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4111; identifier:Journal of clinical imaging science, 11: Article No.15
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.25259/JCIS_6_2020
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4111/1/01%e7%94%b2879%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4111/2/02%e7%94%b2879%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4111/6/03%e7%94%b2879%e6%9c%ac%e6%96%87.pdf fulltext