Effect of Sevoflurane Anesthesia on Intraoperative Spikes, High-Frequency Oscillations, and Phase-Amplitude Coupling in MRI-Normal Hippocampus

• 資料種別: 博士論文
• タイトル: Effect of Sevoflurane Anesthesia on Intraoperative Spikes, High-Frequency Oscillations, and Phase-Amplitude Coupling in MRI-Normal Hippocampus
• 著者・編者: Dahal, Riju; Tamura, Kentaro; Pan, Dong-sheng; Sasaki, Ryota; Takeshima, Yasuhiro; Matsuda, Ryosuke; Yamada, Shuichi; Nishimura, Fumihiko; Nakagawa, Ichiro; Park, Young-Soo; Hayashi, Hironobu; Kawaguchi, Masahiko; Nakase, Hiroyuki
• 著者標目: Dahal, Riju; Tamura, Kentaro; Pan, Dong-sheng; Sasaki, Ryota; Takeshima, Yasuhiro; Matsuda, Ryosuke; Yamada, Shuichi; Nishimura, Fumihiko; Nakagawa, Ichiro; Park, Young-Soo; Hayashi, Hironobu; Kawaguchi, Masahiko; Nakase, Hiroyuki
• 出版事項: Lippincott Williams & Wilkins
• 出版年月日等: 2023-10
• 出版年（W3CDTF）: 2023-10
• 並列タイトル等: MRI 正常海馬における術中棘波，高周波振動および位相振幅結合に対するセボフルラン麻酔の影響
• タイトル（掲載誌）: Journal of Clinical Neurophysiology
• 掲載ページ: 10.1097/WNP.0000000000001031-
• ISSN（掲載誌）: ISSN : 0736-0258
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2024-03-14
• 報告番号: 甲第902号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Hippocampus; high-frequency oscillations; HFO on spike; phase-amplitude coupling; intraoperative electrocorticography; sevoflurane
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; type:Thesis; Introduction: The purpose of this study was to determine the effect of sevoflurane anesthesia on spikes, high-frequency oscillations (HFO), and phase-amplitude coupling using a modulation index (MI) in MRI-normal hippocampus, with the aim of evaluating the utility of intraoperative electrocorticography (ioECOG) in identifying the epileptogenic hippocampus during sevoflurane administration. Methods: Eleven patients with intractable temporal lobe epilepsy with a normal hippocampus on MRI underwent extra-operative electrocorticography (eoECoG) evaluation. Patients were assigned to the Ictal (+) or Ictal (−) group depending on whether the parahippocampal gyrus was included in the seizure onset zone. IoECoG was performed under 0.5 and 1.5 minimum alveolar concentration. The rates of spikes, ripples, fast ripples (FR), ripples on spikes (RonS), fast ripples on spikes (FRonS), and MI HFO (3-4 Hz) were evaluated. Results: During the ioECoG procedure, sevoflurane administration was found to significantly increase the rate of spikes RonS, FRonS and MI HFO (3-4 Hz) in the Ictal (+) group (P < 0.01). In contrast, the Ictal (−) group exhibited a paradoxical increase in the rate of ripples and FR (P < 0.05). Conclusions: Our findings indicate that the administration of sevoflurane during ioECOG in patients with MRI-normal hippocampus can lead to a dose-dependent enhancement of epileptic biomarkers (spikes, RonS, FRonS, and MI (HFO 3-4)) in the epileptogenic hippocampus, while paradoxically increasing the rate of ripples and FR in the non-epileptogenic hippocampus. These results have significant implications for the identification of the MRI-normal hippocampus that requires surgical intervention and preservation of the non-epileptogenic hippocampus.; 権利情報：@ 2023 by the American Clinical Neurophysiology Society. This is a non-final version of an article published in final form in [J Clin Neurophysiol. 2023 Oct 30. doi: 10.1097/WNP.0000000000001031].; identifier:Journal of Clinical Neurophysiology. 2023 Oct, article no.10.1097/WNP.0000000000001031; identifier:0736-0258; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4353; identifier:Journal of Clinical Neurophysiology: 10.1097/WNP.0000000000001031
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4353/1/01%e7%94%b2902%e6%9c%ac%e6%96%87.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4353/2/02%e7%94%b2902%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4353/3/03%e7%94%b2902%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1097/WNP.0000000000001031; https://doi.org/10.1097/WNP.0000000000001031
• 掲載誌（NCID）: AA10625292; https://ci.nii.ac.jp/ncid/AA10625292
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU