Juvenile social isolation immediately affects the synaptic activity and firing property of fast-spiking parvalbumin-expressing interneuron subtype in mouse medial prefrontal cortex

• 資料種別: 博士論文
• タイトル: Juvenile social isolation immediately affects the synaptic activity and firing property of fast-spiking parvalbumin-expressing interneuron subtype in mouse medial prefrontal cortex
• 著者・編者: Okamura, Kazuya; Yoshino, Hiroki; Ogawa, Yoichi; Yamamuro, Kazuhiko; Kimoto, Sohei; Yamaguchi, Yasunari; Nishihata, Yosuke; Ikehara, Minobu; Makinodan, Manabu; Saito, Yasuhiko; Kishimoto, Toshifumi
• 著者標目: Okamura, Kazuya; Yoshino, Hiroki; Ogawa, Yoichi; Yamamuro, Kazuhiko; Kimoto, Sohei; Yamaguchi, Yasunari; Nishihata, Yosuke; Ikehara, Minobu; Makinodan, Manabu; Saito, Yasuhiko; Kishimoto, Toshifumi
• 出版事項: Oxford University Press
• 出版年月日等: 2023-03
• 出版年（W3CDTF）: 2023-03
• 並列タイトル等: マウス内側前頭前野の高速スパイク型parvalbumin発現介在ニューロンの特定のサブタイプへの幼少期社会的孤立直後の影響
• タイトル（掲載誌）: Cerebral Cortex
• 巻号年月日等（掲載誌）: 33 7
• 掲載巻: 33
• 掲載号: 7
• 掲載ページ: 3591-3606
• ISSN（掲載誌）: ISSN : 1047-3211
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2024-03-14
• 報告番号: 甲第923号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: electrophysiology; h-current; neurodevelopment; social deprivation; synapse pruning
• 対象利用者: 一般
• 一般注記: type:Thesis; A lack of juvenile social experience causes various behavioral impairments and brain dysfunction, especially in the medial prefrontal cortex (mPFC). Our previous studies revealed that juvenile social isolation for two weeks immediately after weaning affects the synaptic inputs and intrinsic excitability of fast-spiking parvalbumin-expressing (FSPV) interneurons as well as a specific type of layer 5 (L5) pyramidal cells, which we termed prominent h-current (PH) cells, in the mPFC. However, since these changes were observed at the adult age of postnatal day 65 (P65), the primary cause of these changes to neurons immediately after juvenile social isolation (postnatal day 35) remains unknown. Here, we investigated the immediate effects of juvenile social isolation on the excitability and synaptic inputs of PH pyramidal cells and FSPV interneurons at P35 using whole-cell patch-clamp recording. We observed that excitatory inputs to FSPV interneurons increased immediately after juvenile social isolation. We also found that juvenile social isolation increases the firing reactivity of a subtype of FSPV interneurons, while only a fractional effect was detected in PH pyramidal cells. These findings suggest that juvenile social isolation primarily disturbs the developmental rebuilding of circuits involving FSPV interneurons and eventually affects the circuits involving PH pyramidal cells in adulthood.; 権利情報：© The Author(s) 2022. Published by Oxford University Press. All rights reserved. This is a pre-copyedited, author-produced version of an article accepted for publication in [Cerebral Cortex] following peer review. The version of record [Cereb Cortex. 2023; 33(7): 3591-3606.] is available online at: https://doi.org/10.1093/cercor/bhac294; identifier:Cerebral Cortex. 2023 Mar, vol.33, no.7, p.3591-3606; identifier:1047-3211; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4374; identifier:Cerebral Cortex, 33(7): 3591-3606
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1093/cercor/bhac294
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4374/1/01%e7%94%b2923%e6%9c%ac%e6%96%87.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4374/2/02%e7%94%b2923%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/4374/3/03%e7%94%b2923%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext