著者・編者Wakabayashi, Dai
Kato, Sayaka
Tanaka, Masashi
Yamakage, Hajime
Kato, Hisashi
Kusakabe, Toru
Ozu, Naoki
Kasama, Shu
Kasahara, Masato
Satoh-Asahara, Noriko
Japan Obesity Metabolic Syndrome Study (JOMS) Group
並列タイトル等肥満症の心血管病リスクにおける血清尿酸の新たな病態的意義
タイトル(掲載誌)Diabetes Research and Clinical Practice
一般注記type:Thesis
Aims: This cohort study intended to elucidate the association between serum uric acid (SUA) levels and cardiovascular disease events in Japanese patients with obesity. Methods: Altogether, 450 obese Japanese outpatients were enrolled in a multicenter prospective cohort Japan, the Japan Obesity and Metabolic Syndrome Study. Primary analysis regarding the measurements of cardiovascular risk factors, including SUA levels, and the occurrence of macrovascular complications was based on following the participants over a 5-year period. Results: Of the eligible patients, 335 (74.4%) were followed into the fifth year. During the study period, 15 coronary heart disease, 7 stroke, and 6 arteriosclerosis obliterans events occurred in 39 patients. The CVD incidence rate was 15.8 per 1000 person-years. In the analysis of adjusted models for traditional risk factors, hyperuricemia was a significant factor for the incidence of CVD events, especially in female obese patients. Additionally, we estimated the association between SUA levels and CVD events using cubic spline models, which showed a U-shaped association in both male and female patients. Conclusions: SUA is an effective predictor of CVD events in female obese patients and a risk factor for CVD incident in obese patients.
権利情報:© 2023 Elsevier B.V. All rights reserved.
identifier:Diabetes Research and Clinical Practice. 2023 Nov, vol.205, article no.110919
identifier:0168-8227
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4377
identifier:Diabetes Research and Clinical Practice, 205: 110919
関連情報(DOI)10.1016/j.diabres.2023.110919
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
提供元機関・データベース奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU