並列タイトル等社会的隔離マウスの興奮性・抑制性回路におけるNARPに関連した変化： 自閉スペクトラム症の病態に対する発達上の洞察と示唆
一般注記出版タイプ： VoR
type:Thesis
Background: Social isolation during critical periods of development is associated with alterations in behavior and neuronal circuitry. This study aimed to investigate the immediate and developmental effects of social isolation on firing properties, neuronal activity-regulated pentraxin (NARP) and parvalbumin (PV) expression in the prefrontal cortex (PFC), social behavior in juvenile socially isolated mice, and the biological relevance of NARP expression in autism spectrum disorder (ASD). Methods: Mice were subjected to social isolation during postnatal days 21-35 (P21-P35) and were compared with group-housed control mice. Firing properties in the PFC pyramidal neurons were altered in P35 socially isolated mice, which might be associated with alterations in NARP and PV expression. Results: In adulthood, mice that underwent juvenile social isolation exhibited difficulty distinguishing between novel and familiar mice during a social memory task, while maintaining similar levels of social interaction as the control mice. Furthermore, a marked decrease in NARP expression in lymphoblastoid cell lines derived from adolescent humans with ASD as compared to typically developing (TD) humans was found. Conclusion: Our study highlights the role of electrophysiological properties, as well as NARP and PV expression in the PFC in mediating the developmental consequences of social isolation on behavior.
権利情報：© 2024 Yamaguchi, Okamura, Yamamuro, Okumura, Komori, Toritsuka, Takada, Nishihata, Ikawa, Yamauchi, Makinodan, Yoshino, Saito, Matsuzaki, Kishimoto and Kimoto. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
identifier:Frontiers in Psychiatry. 2024 Jun, vol.15, article no.1403476
identifier:1664-0640
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/4418
identifier:Frontiers in Psychiatry, 15: 1403476
関連情報（DOI）10.3389/fpsyt.2024.1403476
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
提供元機関・データベース奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU