博士論文
デジタルデータあり(長崎大学学術研究成果リポジトリ)
すぐに読む
学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
Prevalence of Zika virus neutralizing antibodies in healthy adults in Vietnam during and after the Zika virus epidemic season: a longitudinal population-based survey
- 資料種別
- 博士論文
- 著者
- Nguyen, Co Thach
- 出版者
- BioMed Central Ltd
- 出版年
- 2020-09-18
- 資料形態
- デジタル
- ページ数・大きさ等
- -
- 授与大学名・学位
- Nagasaki University (長崎大学),博士(医学)
資料に関する注記
一般注記:
- Background: Between 2016 and 2019, 265 cases of Zika virus (ZIKV) infection were reported in Vietnam, predominantly in southern Vietnam. In 2016, a ca...
関連資料・改題前後資料
http://hdl.handle.net/10069/40268
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- Nguyen, Co Thach
- 著者標目
- 出版年月日等
- 2020-09-18
- 出版年(W3CDTF)
- 2020-09-18
- 並列タイトル等
- ジカ熱流行期と流行後におけるベトナム健康人血清中のジカウイルスに対する中和抗体保有率の縦断的調査
- タイトル(掲載誌)
- BMC Infectious Diseases
- 巻号年月日等(掲載誌)
- 20
- 掲載巻
- 20
- 掲載ページ
- 332-
- ISSN(掲載誌)
- ISSN : 1471-2334
- 授与機関名
- Nagasaki University (長崎大学)
- 授与年月日
- 2020-09-18
- 報告番号
- 甲医歯薬第1264号
- 学位
- 博士(医学)
- 本文の言語コード
- eng
- 件名標目
- 対象利用者
- 一般
- 一般注記
- Background: Between 2016 and 2019, 265 cases of Zika virus (ZIKV) infection were reported in Vietnam, predominantly in southern Vietnam. In 2016, a case of ZIKV-associated microcephaly was confirmed in the Central Highlands, and several members of the infant’s family were confirmed to be infected with ZIKV. The study aims to determine the level of immunity to ZIKV in the general population of the ZIKV epidemic region. Methods: A total of 879 serum samples were collected from 801 participants between January 2017 and July 2018, during and after the ZIKV epidemic in Vietnam. The samples were tested for anti-ZIKV immunoglobulin M (IgM) and immunoglobulin G (IgG), and anti-dengue virus (DENV) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Plaque-reduction neutralization test (PRNT) for ZIKV was performed on all samples, and for DENV on the samples that ZIKV neutralizing antibody positive. Results: A total of 83 (10.3%) participants had anti-ZIKV IgM. Of the 83, 6 were confirmed to be ZIKV antibodies positive using PRNT and anti-ZIKV IgG ELISA. Of the 718 participants who were anti-ZIKV IgM negative, a further 3 cases were confirmed as positive for antibodies against ZIKV. Of the 9 participants with ZIKV infection, 5 lived in the same village as the infant with ZIKV-associated microcephaly and the other 4 lived in 2 neighboring communes. Repeat samples were collected from the 83 ZIKV IgM positive participants 1.5?years after the first collection. No new cases of ZIKV infection were detected. In addition, 2 of 3 participants with anti-ZIKV NS1 IgG demonstrated a 4- to 8-fold increase in ZIKV neutralizing antibody titer. Conclusions: ZIKV was present in the area around Krong Buk, with the rate of ZIKV-specific antibodies was 1.1% in the community since at least 2016. While the low levels of circulation together with low seroprevalence suggests a limited outbreak in the region, the results also reflect on low levels of protective immunity to Zika within the population. These results provide a better understanding of the current ZIKV epidemic status in the region and demonstrate a need for implementation of more effective ZIKV infection control measures.長崎大学学位論文 学位記番号:博(医歯薬)甲第1264号 学位授与年月日:令和2年9月18日Author: Co Thach Nguyen, Meng Ling Moi, Thi Quynh Mai Le, Thi Thu Thuy Nguyen, Thi Bich Hau Vu, Hai Tuan Nguyen, Thi Thu Hang Pham, Thi Hien Thu Le, Le Manh Hung Nguyen, Minh Huong Phu Ly, Chris Fook Sheng Ng, Taichiro Takemura, Kouichi Morita & Futoshi HasebeCitation: BMC Infectious Diseases, 20, 332; 2020identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-18)
- 一次資料へのリンクURL
- https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=45&item_no=1&attribute_id=70&file_no=1 (fulltext)
- オンライン閲覧公開範囲
- インターネット公開
- 著作権情報
- c The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- 関連情報
- http://hdl.handle.net/10069/40268
- 関連情報(DOI)
- 10.1186/s12879-020-05042-2
- 連携機関・データベース
- 国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
- 提供元機関・データベース
- 長崎大学 : 長崎大学学術研究成果リポジトリ