Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study

• 資料種別: 博士論文
• タイトル: Health-related quality of life in Japanese patients with prostate cancer following proton beam therapy: an institutional cohort study
• 著者・編者: 松川, 京子
• 著者標目: 松川, 京子
• 出版事項: Oxford University Press
• 出版年月日等: 2020-09-02
• 出版年（W3CDTF）: 2020-09-02
• 並列タイトル等: 日本における前立腺癌患者の陽子線治療による健康関連QOL：単施設コホート研究
• タイトル（掲載誌）: Japanese Journal of Clinical Oncology
• 巻号年月日等（掲載誌）: 50 5
• 掲載巻: 50
• 掲載号: 5
• 掲載ページ: 519-527
• ISSN（掲載誌）: ISSN : 1465-3621
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2020-09-02
• 報告番号: 甲医歯薬第1281号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: prostate cancer; proton beam therapy; health-related quality of life; Japanese patients
• 対象利用者: 一般
• 一般注記: Objective: Many treatment options have guaranteed long-term survival in patients with localized prostate cancer and health-related quality of life has become a greater concern for those patients. The purpose of this study was to reveal the health-related quality of life after proton beam therapy and to clarify the differences from other treatment modalities for prostate cancer. Methods: Between January 2011 and April 2016, 583 patients were enrolled in the study and health-related quality of life outcomes using the Expanded Prostate Cancer Index Composite questionnaire were evaluated and compared with previous research targeted at Japanese patients. Results: We found a significant decrease in the least square mean scores for urinary and bowel domains excluding the incontinence subscale after proton beam therapy (P < 0.0001) and recovery at a year following treatment. The scores for sexual function in patients without androgen deprivation therapy decreased each year after proton beam therapy (P < 0.0001). The scores for hormones in patients without androgen deprivation therapy remained high and those of patients with androgen deprivation therapy were lower before treatment but were comparable to those of non-androgen deprivation therapy patients at 2 years post-treatment. We found that the impact of radiotherapy including proton beam therapy on urinary condition and sexual function was lower than that of surgery. Conclusions: For the first time in Japan, we investigated health-related quality of life using Expanded Prostate Cancer Index Composite questionnaires in patients with prostate cancer after proton beam therapy and compared it with other treatment modalities.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1281号 学位授与年月日:令和2年9月2日; Author: Kyoko Matsukawa, Takeshi Arimura, Makiko Orita, Hisayoshi Kondo, Ikuko Chuman, Takashi Ogino, Yasuyuki Taira, Takashi Kudo, Noboru Takamura; Citation: Japanese Journal of Clinical Oncology, 50(5), pp.519?527; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
• 一次資料へのリンクURL: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=65&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=65&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: c The Author(s) 2020. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [e-mail]
• 関連情報: http://hdl.handle.net/10069/40352
• 関連情報（DOI）: 10.1093/jjco/hyaa027
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ