並列タイトル等非小細胞肺癌に対する肺切除術後の運動耐容能に影響を及ぼす要因
タイトル(掲載誌)Integrative Cancer Therapies
授与機関名Nagasaki University (長崎大学)
一般注記Purpose: We investigated, in patients who underwent lung resection for non?small cell lung cancer (NSCLC), the magnitude of early limitation in functional exercise capacity and the associations with pre- and postoperative factors. Methods: Consecutive patients with preoperative clinical stage I to IIIA NSCLC who underwent lung resection were prospectively enrolled. We measured functional exercise capacity (6-minute walk distance [6MWD]) and skeletal muscle strength (handgrip [HF] and quadriceps force [QF]) within 2 days prior to surgery and on day 7 postoperatively. Results: Two hundred eighteen participants were recruited (median age 69 years) of whom 49 developed postoperative complications (POCs). 6MWD was markedly decreased (514 m vs 469 m, P < .001); HF and QF were slightly decreased following surgery. Multiple linear regression showed that preoperative vital capacity (P < .01), QF (P < .05), the duration of chest tube drainage (P < .001), and presence of POCs (P < .05) were significant predictors. However, intraoperative factors were not significantly associated with the decline in 6MWD. Conclusions: These results suggest that patients with preoperative impairments in pulmonary function and muscle strength, and those who require prolonged chest tube drainage or develop POCs are likely to have impaired exercise capacity. Therefore, individual assessment and follow-up of patients with such factors is indicated.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1260号 学位授与年月日:令和2年6月3日
Author: Masato Oikawa, Masatoshi Hanada, Hiroki Nagura, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Terumitsu Sawai, Naoya Yamasaki, Takeshi Nagayasu, Ryo Kozu
Citation: Integrative Cancer Therapies, 19, 1534735420923389; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03)
一次資料へのリンクURLhttps://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=848&item_no=1&attribute_id=70&file_no=1 (fulltext)
著作権情報c The Author(s) 2020 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages(https://us.sagepub.com/en-us/nam/open-access-at-sage).
関連情報http://hdl.handle.net/10069/40087
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)