博士論文
デジタルデータあり(長崎大学学術研究成果リポジトリ)
すぐに読む
学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
Characteristics and Biomarkers of Patients with Central Nervous System Infection Admitted to a Referral Hospital in Northern Vietnam
- 資料種別
- 博士論文
- 著者
- Ngo, Chi Cuong
- 出版者
- BioMed Central Ltd
- 出版年
- 2021-06-02
- 資料形態
- デジタル
- ページ数・大きさ等
- -
- 授与大学名・学位
- Nagasaki University (長崎大学),博士(医学)
資料に関する注記
一般注記:
- Background: Laboratory facilities for etiological diagnosis of central nervous system (CNS) infection are limited in developing countries; therefore, ...
関連資料・改題前後資料
http://hdl.handle.net/10069/00040840
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デジタル
- 資料種別
- 博士論文
- 著者・編者
- Ngo, Chi Cuong
- 著者標目
- 出版年月日等
- 2021-06-02
- 出版年(W3CDTF)
- 2021-06-02
- 並列タイトル等
- 北ベトナムの高度医療施設に入院した中枢神経系感染症の患者の特質およびバイオマーカーについて
- タイトル(掲載誌)
- Tropical Medicine and Health
- 巻号年月日等(掲載誌)
- 49
- 掲載巻
- 49
- 掲載ページ
- 42-
- ISSN(掲載誌)
- ISSN : 1349-4147
- 授与機関名
- Nagasaki University (長崎大学)
- 授与年月日
- 2021-06-02
- 報告番号
- 甲医歯薬第1357号
- 学位
- 博士(医学)
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- Background: Laboratory facilities for etiological diagnosis of central nervous system (CNS) infection are limited in developing countries; therefore, patients are treated empirically, and the epidemiology of the pathogens is not well-known. Tubercular meningitis is one of the common causes of meningitis, which has high morbidity and mortality, but lacks sensitive diagnostic assays. The objectives of this study were to determine the causes of meningitis in adult patients by using molecular assays, to assess the risk factors associated with them, and to explore whether biomarkers can differentiate tubercular meningitis from bacterial meningitis.Methods: We conducted a cross-sectional study in the Department of Infectious Diseases, Bach Mai Hospital, Hanoi, Vietnam, from June 2012 to May 2014. All patients who were ≥ 16 years old and who had meningoencephalitis suggested by abnormal cerebrospinal fluid (CSF) findings (CSF total cell >5/mm3 or CSF protein ≥40 mg/dL) were included in the study. In addition to culture, CSF samples were tested for common bacterial and viral pathogens by polymerase chain reaction (PCR) and for biomarkers: C-reactive protein and adenosine deaminase (ADA).Results: Total number of patients admitted to the department was 7506; among them, 679 were suspected to have CNS infection, and they underwent lumbar puncture. Five hundred eighty-three patients had abnormal CSF findings (meningoencephalitis); median age was 45 (IQR 31–58), 62.6% were male, and 60.9% were tested for HIV infection. Among 408 CSF samples tested by PCR, out of them, 358 were also tested by culture; an etiology was identified in 27.5% (n=112). S. suis (8.8%), N. meningitis (3.2%), and S. pneumoniae (2.7%) were common bacterial and HSV (2.2%), Echovirus 6 (0.7%), and Echovirus 30 (0.7%) were common viral pathogens detected. M. tuberculosis was found in 3.2%. Mixed pathogens were detected in 1.8% of the CSF samples. Rural residence (aOR 4.1, 95% CI 1.2–14.4) and raised CSF ADA (≥10 IU/L) (aOR 25.5, 95% CI 3.1–212) were associated with bacterial meningitis when compared with viral meningitis; similarly, raised CSF ADA (≥10 IU/L) (aOR 42.2, 95% CI 2.0–882) was associated with tubercular meningitis.Conclusions: Addition of molecular method to the conventional culture had enhanced the identification of etiologies of CNS infection. Raised CSF ADA (≥10 IU/L) was strongly associated with bacterial and tubercular meningitis. This biomarker might be helpful to diagnose tubercular meningitis once bacterial meningitis is ruled out by other methods.長崎大学学位論文 学位記番号:博(医歯薬)甲第1357号 学位授与年月日:令和3年6月2日Author: Cuong Chi Ngo, Shungo Katoh, Futoshi Hasebe, Bhim Gopal Dhoubhadel, Tomoko Hiraoka, Sugihiro Hamaguchi, Anh Thi Kim Le, Anh Thi Hien Nguyen, Anh Duc Dang, Chris Smith, Lay-Myint Yoshida, Cuong Duy Do, Thuy Thi Thanh Pham and Koya AriyoshiCitation: Tropical Medicine and Health, 49, art. no. 42; 2021identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02)
- 一次資料へのリンクURL
- https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=26674&item_no=1&attribute_id=70&file_no=1 (fulltext)
- オンライン閲覧公開範囲
- インターネット公開
- 著作権情報
- © The Author(s). 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
- 関連情報
- http://hdl.handle.net/10069/00040840
- 関連情報(DOI)
- 10.1186/s41182-021-00322-2
- 連携機関・データベース
- 国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
- 提供元機関・データベース
- 長崎大学 : 長崎大学学術研究成果リポジトリ