Nuclear expression of Pygo2 correlates with poorly differentiated state involving c-Myc, PCNA and Bcl9 in Myanmar hepatocellular carcinoma

• 資料種別: 博士論文
• タイトル: Nuclear expression of Pygo2 correlates with poorly differentiated state involving c-Myc, PCNA and Bcl9 in Myanmar hepatocellular carcinoma
• 著者・編者: HTUN, MYO WIN
• 著者標目: HTUN, MYO WIN
• 出版事項: The Japan Society of Histochemistry and Cytochemistry
• 出版年月日等: 2022-03-18
• 出版年（W3CDTF）: 2022-03-18
• 並列タイトル等: ミャンマー人低分化型肝細胞がんに於ける核内Pygo2のc-Myc, PCNA, Bcl9との相関的発現上昇
• タイトル（掲載誌）: Acta Histochemica et Cytochemica
• 巻号年月日等（掲載誌）: 54 6
• 掲載巻: 54
• 掲載号: 6
• 掲載ページ: 195-206
• ISSN（掲載誌）: ISSN : 0044-5991; ISSN : 1347-5800
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-03-18
• 報告番号: 甲医歯薬第1417号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: Pygo2; Bcl9; c-Myc; PCNA; Myanmar hepatocellular carcinoma
• 対象利用者: 一般
• 一般注記: 出版タイプ： VoR; In Myanmar, hepatocellular carcinoma (HCC) is commonly seen in young adult and associated with poor prognosis, while the molecular mechanisms that characterize HCC in Myanmar are unknown. As co-activation of Wnt/β-catenin signaling and c-Myc (Myc) are reported to associate with malignancy of HCC, we immunohistochemically investigated the expression of Pygo2 and Bcl9, the co-activators of the Wnt/β-catenin signaling, Myc and PCNA in 60 cases of Myanmar HCC. Pygo2 expression was confirmed by in situ hybridization. The signal intensity was measured by image analyzer and then statistically analyzed. As a result, the expression of Pygo2 was significantly higher in HCC compared to normal liver tissue and the nuclear signal was the most intense in poorly differentiated HCC. Cytoplasmic Bcl9 was expressed in the normal liver tissue but decreased in HCC with the progression of histopathological grade. Myc was significantly higher in poorly differentiated HCC, whereas PCNA labeling index increased with the progression of histopathological grade. Nuclear Pygo2 showed strong correlation with nuclear Myc (P < 0.01) and PCNA (P < 0.001), and inversely correlated with cytoplasmic Bcl9 (P < 0.01). Our results suggested Wnt/β-catenin and Myc signaling is commonly activated in Myanmar HCC and that the correlative upregulation of nuclear Pygo2 and Myc characterizes the malignant features of HCC in Myanmar.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1417号 学位授与年月日:令和4年3月18日; Author: Myo Win Htun, Yasuaki Shibata, Kyaw Soe, Takehiko Koji; Citation: Acta Histochemica et Cytochemica, 54(6), pp. 195-206; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
• 一次資料へのリンクURL: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27435&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2021 The Japan Society of Histochemistry and Cytochemistry
• 関連情報: http://hdl.handle.net/10069/00041420
• 関連情報（DOI）: 10.1267/ahc.21-00090; https://doi.org/10.1267/ahc.21-00090
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ