Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial

• 資料種別: 博士論文
• タイトル: Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial
• 著者・編者: 壱岐尾, 優太
• 著者標目: 壱岐尾, 優太
• 出版事項: Springer Nature
• 出版年月日等: 2022-06-01
• 出版年（W3CDTF）: 2022-06-01
• 並列タイトル等: 化学療法誘発性末梢神経障害患者に対する複合的な手指運動介入の有効性：パイロットランダム化比較試験
• タイトル（掲載誌）: Supportive Care in Cancer
• 巻号年月日等（掲載誌）: 30
• 掲載巻: 30
• 掲載ページ: 4981-4992
• ISSN（掲載誌）: ISSN : 0941-4355; ISSN : 1433-7339
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2022-06-01
• 報告番号: 甲医歯薬第1459号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: Chemotherapy; Peripheral neuropathy; Hand exercise; Upper-extremity function
• 対象利用者: 一般
• 一般注記: Purpose Previous evidence regarding the impact of exercise interventions on chemotherapy-induced peripheral neuropathy often focuses on lower-extremity functions, such as muscle strength and balance ability, while their efects on upper extremities remain unknown. We aimed to evaluate the efcacy of combined hand exercise intervention on upper-extremity function, symptoms, and quality-of-life in patients with chemotherapy-induced peripheral neuropathy (CIPN). Methods After screening 341 patients, 42 were randomly assigned to either the intervention (n=21) or control (n=21) group. Participants were evaluated at baseline (T0) and after one (T1) and two (T2) chemotherapy cycles. The primary outcome was upper-extremity function measured using the Michigan Hand Outcomes Questionnaire (MHQ) at T2. The intention-to-treat and as-treated populations were compared using a mixed-efect model. Results In the intention-to-treat analysis, the decline in activities of daily living of MHQ was signifcantly suppressed in the intervention group compared with that in the control group at T2 (diference: 7.23; 95% confdence interval: 0.35–14.10). Similarly, in the as-treated analysis, the decline in activities of daily living of MHQ was signifcantly suppressed in the intervention group compared with that in the control group at T2 (diference: 13.09; 95% confdence interval: 5.68–20.49). Pain also signifcantly improved in the intervention group compared with that in the control group at T2 (diference: 13.21; 95% confdence interval:−22.91 to−3.51). Conclusion The combined hand exercise intervention may improve upper-extremity function, such as by suppressing decline in ADL, and reduce pain in patients with CIPN.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1459号 学位授与年月日:令和4年6月1日; Author: Yuta Ikio, Akira Sagari, Akira Nakashima, Daiki Matsuda, Terumitsu Sawai, Toshio Higashi; Citation: Supportive Care in Cancer, 30, pp.4981-4992; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
• 一次資料へのリンクURL: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27487&item_no=1&attribute_id=70&file_no=2
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022, corrected publication 2022. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00520-022-06846-5
• 関連情報: http://hdl.handle.net/10069/00041589
• 関連情報（DOI）: 10.1007/s00520-022-06846-5
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ