並列タイトル等日本への輸入農産物に付着したアゾール耐性Aspergillus fumigatusの特徴について
タイトル（掲載誌）Journal of Infection and Chemotherapy
授与機関名Nagasaki University (長崎大学)
一般注記Due to the increase in the number of azole-resistant Aspergillus fumigatus, there is an urgent need of data to predict future trends and prevent further spreading. The intercountry transfer of resistant A. fumigatus on plant bulbs have been reported. We investigated existence and characteristics of resistant isolates attached to agricultural products imported to Japan. We purchased 292 samples in Japan. All samples were screened for the existence of azole-resistant A. fumigatus. For positive isolates, minimum inhibitory concentrations of the drugs were determined. We also analyzed Cyp51A, Hmg1, and Erg6 mutations of these isolates and conducted microsatellite genotyping. Fourteen azole-resistant isolates were detected, of which 13 were cultured from flower bulbs imported from the Netherlands. Among them 5 were from 11 bulbs of Hippeastrum (45.5%), 5 were from 24 bulbs of Gladiolus (20.8%), 2 were from 4 bulbs of Ixia (50.0%), and 1 was from 22 bulbs of Tulipa (4.5%). Only 1 resistant isolate was cultured from the 10 bulbs of Narcissus (10.0%) originating in Japan. Various novel mutations including Y121F/T289A in Cyp51A with no tandem repeat in promoter region were discovered from imported strains. Our study provides important data showing that agricultural imports provide a possible route for their intercontinental spread and raises the concern that strains harboring highly diverse Cyp51A mutations might increase in clinical settings in the future.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1478号 学位授与年月日:令和4年12月7日
Author: Yuichiro Nakano, Masato Tashiro, Ryo Urano, Minori Kikuchi, Naoki Ito, Eriko Moriya, Tomoyuki Shirahige, Maki Mishima, Takahiro Takazono, Taiga Miyazaki, Koichi Izumikawa
Citation: Journal of Infection and Chemotherapy, 26(10), pp.1021-1025; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-12-07)
一次資料へのリンクURLhttps://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27898&item_no=1&attribute_id=70&file_no=1 （fulltext）
著作権情報© 2020 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
関連情報http://hdl.handle.net/10069/00041985
関連情報（DOI）10.1016/j.jiac.2020.05.008
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）