並列タイトル等組織学的スコアに基づく膠原病関連間質性肺炎の認識-オンライン診断決定支援ツールの検証
授与機関名Nagasaki University (長崎大学)
一般注記出版タイプ： VoR
Objectives: to evaluate the number of cases of idiopathic pulmonary fibrosis (IPF) that included histological features of connective tissue disease (CTD) and to check whether they demonstrated the clinical features of CTD, using a previously reported CTD-interstitial pneumonia (IP) index that histologically differentiates CTD-associated and idiopathic IP. Methods: patients diagnosed with IPF following video-assisted thoracoscopic biopsy through multidisciplinary team diagnosis between 2014 and 2017 were selected. Pathological observation was made by four pathologists who scored eight observational items needed for the CTD-IP index. Cases determined as CTD, by the CTD-IP index, were extracted, and their clinical features were compared. Results: a total of 94 cases of IPF were identified, of which 20 were classified into the CTD group using the CTD-IP index with reasonable interobserver agreement (k = 0.76). Cases pathologically classified into the CTD group were significantly associated with female sex, non-smoking history, autoantibody positivity, and CTD symptoms (p = 0.01, 0.03, 0.01, and 0.04, respectively). Conclusions: patients with IPF with pathological findings of CTD showed clinical characteristics similar to those of patients with CTD.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1511号 学位授与年月日:令和5年3月20日
Author: Mutsumi Ozasa, Yoshiaki Zaizen, Kazuhiro Tabata, Kensuke Kataoka, Shuntaro Sato, Andrey Bychkov, Noriho Sakamoto, Hiroshi Mukae, Yasuhiro Kondoh, Junya Fukuoka
Citation: Diagnostics, 11(8), art. no. 1359; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-20)
関連情報http://hdl.handle.net/10069/00042244
関連情報（DOI）10.3390/diagnostics11081359
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）