Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis

• 資料種別: 博士論文
• タイトル: Association between acetylcholine receptor characteristics in biceps motor endplates and the epidemiological predictors for conversion from ocular to generalized myasthenia gravis
• 著者・編者: 島, 智秋
• 著者標目: 島, 智秋
• 出版事項: Nagasaki University School of Medicine
• 出版年月日等: 2023-03-20
• 出版年（W3CDTF）: 2023-03-20
• 並列タイトル等: 眼筋型重症筋無力症における、上腕二頭筋運動終板のアセチルコリン受容体量と全身型への疫学的転換予測因子との関連
• タイトル（掲載誌）: ACTA MEDICA NAGASAKIENSIA
• 巻号年月日等（掲載誌）: 66 1
• 掲載巻: 66
• 掲載号: 1
• 掲載ページ: 21-27
• ISSN（掲載誌）: ISSN : 0001-6055
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2023-03-20
• 報告番号: 甲医歯薬第1520号
• 学位: 博士(医学)
• 本文の言語コード: eng
• 件名標目: ocular myasthenia gravis; secondary generalized myasthenia gravis; acetylcholine receptor antibody; motor endplate
• 対象利用者: 一般
• 一般注記: Objective: Epidemiological studies have identified various predictors of conversion from ocular myasthenia gravis (OMG) to secondary generalized myasthenia gravis (SGMG), but none have been confirmed. We investigated the effects of the epidemiological conversion predictors on the destruction of motor endplates in the biceps of patients with OMG and attempted to identify predictors of conversion to SGMG histologically.Methods: Patients with clinically diagnosed OMG who requested immunohistological diagnosis and who underwent muscle biopsy were included in this study. We immunostained the biceps motor endplate and semi-quantitatively measured the density and number of AChRs to determine their association with the epidemiological predictors of conversion from OMG to SGMG.Results: Thirteen patients with OMG were included, of which two patients with positive AChR antibody and concomitant thymoma converted to SGMG. In the classification according to the presence of AChR antibody, the AChR densities tended to be lower in the antibody-positive group than in the negative group (p=0.079), and the AChR numbers were significantly lesser in the AChR antibody-positive group than in the negative group (p=0.019). There were no differences in AChR densities or numbers according to sex, presence of thymic abnormalities, or presence of comorbid autoimmune diseases.Conclusion: In OMG, the AChR numbers in motor endplates of the biceps were significantly lesser in the AChR antibodypositive group than in the negative group. Since the muscle strength tends to decrease as the number of AChRs decreases, AChR antibody positivity may be a predictor of OMG to SGMG conversion, but further studies are needed to confirm.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1520号 学位授与年月日:令和5年3月20日; Author: Tomoaki Shima, Atsushi Nagaoka, Shunsuke Yoshimura, Akira Tsujino; Citation: Acta Medica Nagasakiensia, 66(1), pp.21−27; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-20)
• 一次資料へのリンクURL: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28227&item_no=1&attribute_id=70&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 関連情報: http://hdl.handle.net/10069/00042253
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 長崎大学 : 長崎大学学術研究成果リポジトリ