並列タイトル等ラットの咬筋量低下による実験的歯の移動への影響について
タイトル（掲載誌）Journal of Oral Rehabilitation
授与機関名Nagasaki University (長崎大学)
一般注記Background: Previous clinical observational studies have suggested that orthodontic tooth movement (OTM) is related, at least partly, to the mass and/or capabilities of the masticatory muscles.Objectives: Our study aimed to examine the influence of masticatory muscle mass on the OTM in an animal experimental model in which the masseter muscle was modulated by botulinum neurotoxin type A (BTX) injection.Methods: Eighteen Wistar rats were equally divided into two groups: BTX injection and control. BTX was injected bilaterally into the masseter muscles. Three days after the injection, the maxillary left first molars were orthodontically moved for 14 days. At the end of the experiment, micro-computed tomography was performed to evaluate the rate of OTM and bone morphometry. The masseter muscles were weighed and prepared for histological analyses.Results: The masseter muscle mass in the BTX group was less than that in the control group, and histological findings showed atrophy of muscle fibres. The rate of OTM was significantly higher in the BTX group than in the control group. Furthermore, a negative correlation was detected between masseter muscle mass and OTM in the BTX group. Bone morphometry showed no difference between the control and BTX groups.Conclusion: Decreased masseter muscle mass was found to be closely related to an increase in the rate of OTM in rats using BTX injection to modify the masseter muscle mass. Masseter muscle mass could be a predictive factor for OTM in rats injected with BTX.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1496号 学位授与年月日:令和5年3月1日
Author: Keira Arizono-Shimada, Hitoshi Hotokezaka, Yukiko Morita, Airi Ino-Kondo, Yuika Ueda-Ichinose, Yukako Nashiro, Yuka Hotokezaka, Keiko Yoshimi, Stavros Kiliaridis, Noriaki Yoshida
Citation: Journal of Oral Rehabilitation, 49(10), pp. 1012-1019; 2022
identifier:Nagasaki University (長崎大学), 博士(歯学) (2023-03-01)
一次資料へのリンクURLhttps://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28234&item_no=1&attribute_id=70&file_no=1 （fulltext）
著作権情報© 2022 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Journal of Oral Rehabilitation, 49(10), pp. 1012-1019; 2022, which has been published in final form at https://doi.org/10.1111/joor.13357. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley's version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
関連情報http://hdl.handle.net/10069/00042229
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）