Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC

• 資料種別: 博士論文
• タイトル: Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC
• 著者・編者: Ariyoshi, Jumpei
• 著者標目: Ariyoshi, Jumpei
• 出版年月日等: 2017-03-24
• 出版年（W3CDTF）: 2017-03-24
• 並列タイトル等: RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発
• 授与機関名: 京都工芸繊維大学
• 授与年月日: 2017-03-24
• 報告番号: 甲第821号
• 学位: 博士（学術）
• 本文の言語コード: eng
• 件名標目: microRNA; RNA-induced silencing complex; RISC; Non-coding RNA; Anti-miRNA oligonucleotide; AMO
• 対象利用者: 一般
• 一般注記: type:Thesis; MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, aberrant expressions of miRNAs in several pathological processes, including those in cancers, have been described. Therefore, miRNAs have been considered as promising therapeutic targets. The miRNA duplex associates with the Argonaute protein (Ago) to form ribonucleoprotein complexes called RNA-induced silencing complex (RISC). MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. This study presents development of the novel anti-miRNA oligonucleotides (AMOs) to promote the release of miRNA from RISC.
• 記録形式（IMT）: application/pdf
• 一次資料へのリンクURL: fulltext; http://repository.lib.kit.ac.jp/repo/repository/10212/2379/D1-0821_h1.pdf; http://repository.lib.kit.ac.jp/repo/repository/10212/2379/D1-0821.pdf
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 京都工芸繊維大学 : ＫＩＴ学術成果コレクション