文書・図像類
Multilateral understanding of hot springs by omics-based approaches
Multilateral understanding of hot springs by omics-based approaches
資料に関する注記
一般注記:
- type:textHot springs are unique natural environments that have been used for recreational and/or therapeutic purposes (balneotherapy) since ancient ti...
書店で探す
全国の図書館の所蔵
国立国会図書館以外の全国の図書館の所蔵状況を表示します。
所蔵のある図書館から取寄せることが可能かなど、資料の利用方法は、ご自身が利用されるお近くの図書館へご相談ください
その他
慶應義塾大学学術情報リポジトリ
デジタル連携先のサイトで、学術機関リポジトリデータベース(IRDB)(機関リポジトリ)が連携している機関・データベースの所蔵状況を確認できます。慶應義塾大学学術情報リポジトリのサイトで この本を確認
書店で探す
書誌情報
この資料の詳細や典拠(同じ主題の資料を指すキーワード、著者名)等を確認できます。
デジタル
- 資料種別
- 文書・図像類
- 著者・編者
- 村上, 慎之介
- 著者標目
- 出版事項
- 出版年月日等
- 2015
- 出版年(W3CDTF)
- 2015
- タイトル(掲載誌)
- 生命と情報
- 巻号年月日等(掲載誌)
- 22
- 掲載巻
- 22
- 掲載ページ
- 11-25
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- type:textHot springs are unique natural environments that have been used for recreational and/or therapeutic purposes (balneotherapy) since ancient times in various countries, especially, Japan. Japanese hot spring therapy, called "touji", is world-renowned. Multilateral and comprehensive scientific study of hot springs and their benefits could contribute to making Japan a tourism-oriented country. As a first step, microbes living in hot springs and their genes were analyzed to understand the hot spring mircobiome. We detected 27 novel microorganisms and type-specific tRNA degradation. Hot spring water (HSW) consumption is one of the methods of balneotherapy. It has been reported that consumption of hydrogen carbonate- or sulfur-containing water may be prevent and/or improve type 2 diabetes. However, since the molecular mechanisms underlying the effects of balneotherapy have not been well elucidated, the physiological effects of HSW consumption were evaluated using omics-based approaches. In the HSW consumption periods, serum glycoalbumin levels, a glycemic control index, were significantly decreased. Metabolome analysis showed that concentrations of 19 blood metabolites including 4 glycolysis-related metabolites and 3 amino acids were significantly changed in the HSW consumption periods as compared with the tap water consumption periods, suggesting that HSW consumption may induce glycolysis and proteolysis alteration. Additionally, 8 families of gut microbiota were significantly changed, out of which lean-associated bacteria was significantly increased. Moreover, experiment on murine models was also conducted and these models may be useful for screening to evaluate the effectiveness of HSW consumption. The current research provides beneficial information for future studies investigating the molecular basis of balneotherapy. Taken together, our findings provide new insights into the microbial ecosystems in hot springs and the molecular mechanisms underlying the effects of balneotherapy. These findings contribute to the understanding of hot springs and their effect in improving human health.慶應義塾大学湘南藤沢キャンパス先端生命科学研究会 2015年度学生論文集 博士論文ダイジェストidentifier:SFC-RM2015-002identifier:請求記号:
- 一次資料へのリンクURL
- https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KO92001004-00000022-0011
- オンライン閲覧公開範囲
- 限定公開
- 連携機関・データベース
- 国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)
- 提供元機関・データベース
- 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ