並列タイトル等The epidemiological study on human adverse health effects 30 years after sprayed dioxins polluted environment in Vietnam
タイトル（掲載誌）平成16(2004)年度 科学研究費補助金 基盤研究(B) 研究成果報告書 = 2004 Fiscal Year Final Research Report
一般注記2002年より2004年までの3年間に、ベトナム中部の枯葉剤撒布地Quang Tri省Cam Chinh村と対照地区Ha Tinh省Cam Phuc村の住民調査を計4回実施した。血液、母乳、皮下脂肪を生体試料として採取し、凍結保存して日本国内に搬送した。各試料中のダイオキシン類とその異性体の濃度を高感度質量分析計にてTEQ換算で測定した。その結果、いずれの試料においても、汚染地区住民のダイオキシン類濃度が統計学的に有意な高値を示した。但し、異性体比率では最も毒性が強い2,3,7,8-TCDDの占有率は20%以下で、むしろ5,6塩化の比率が高く、この結果は従来の報告と異なる。血清生化学検査では、甲状腺や月刊蔵の機能検査で両群間に系統的な差は見られなかった。血清コリンエステラーゼ値が母乳中のダイオキシン類濃度と負の相関を示した。児の身体計測値も両群間に有意差は見られなかったが、児の胸囲と母乳中のダイオキシン類濃度との問には負の相関がみられた。両指標は重回帰分析の結果でも、母親や児の年齢(月齢)を考慮に入れても、母乳中のダイオキシン類濃度と有意な関連性を示した。
To examine dioxins levels in human specimen including breast milk, adipose tissue and serum and their relation with human adverse health effects over 30 years after sprayed dioxins polluted Vietnamese environment, Vietnamese inhabitants of two villages in central part of Vietnam were selected in four examinations between 2002 and 2004. Dioxin-exposed area is located in Cam Chinh commune in Quang Tri province where herbicides were sprayed (abbreviate Quang Tri to QT), while Cam Phuc commune in Ha Tinh province (abbreviate Ha Tinh to HT) is selected as control area where herbicides were not sprayed during the War. These two communes were separated by the demilitarized zone of latitude 17 degrees north line that was a military boundary in Vietnam War.Quantitation was performed by a high resolution mass spectrometer (HRMS ; JEOL MStation-JMS700) equipped with a gas chromatograph (HP-6980).Dioxin levels of human samples including breast milk, adipose tissue and serum in people in herbicide-exposed area in Vietnam is significantly higher than those in people in dioxin-unexposed control area. However, TCDD contributed less than 20% of the total I-TEQ in most samples. These results were different from the former reports that TCDD was a useful indicator for toxicity of Agent Orange since TCDD occupied most of dioxins. It is necessary to investigate the origin of 1,2,3,7,8-PCDD and 2,3,4,7,8-PCDF which were the most contributor in the total TEQ in this study.Biochemical indicators in sera such as liver or thyroid functions were not significantly different between two groups. Significant negative correlations were showed between Total PCDD/Fs and cholinesterase of mothers. Dioxin concentration in breast milk has significant association with chest measurement of infants after adjustment of age of infants although our results did not show difference between the growths of infants in two areas.
研究課題/領域番号:14406011, 研究期間(年度):2002-2004
出典：「ベトナムにおけるダイオキシン類環境汚染30年後の生体影響に関する疫学的研究」研究成果報告書 課題番号14406011 (KAKEN：科学研究費助成事業データベース（国立情報学研究所）) 本文データは著者版報告書より作成
一次資料へのリンクURLhttps://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44424&item_no=1&attribute_id=26&file_no=1
関連情報https://kaken.nii.ac.jp/search/?qm=20167373
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14406011/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-14406011/144060112004kenkyu_seika_hokoku_gaiyo/
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）