Formin-like 1(FMNL1)は膠芽腫のmesenchymal subtypeに関連し、独立した予後不良因子である

• 資料種別: 博士論文
• タイトル: Formin-like 1(FMNL1)は膠芽腫のmesenchymal subtypeに関連し、独立した予後不良因子である
• 著者・編者: 比嘉, 那優大
• 著者標目: 比嘉, 那優大 ヒガ, ナユタ
• 出版事項: MDPI journals
• 並列タイトル等: Formin-like 1(FMNL1) Is Associated with Glioblastma Multiforme Mesenchymal Subtype and Independently Prediots Poor Prognosis
• 授与機関名: 鹿児島大学
• 授与年月日: 2020-03-25
• 報告番号: 甲総研第550号
• 学位: 博士(医学); Doctor of Philosophy in Medical Science
• 本文の言語コード: eng
• 件名標目: formin-like 1 (FMNL1); DIAPH1; GOLGA2; invasion; migration; mesenchymal subtype
• 対象利用者: 一般
• 一般注記: 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by rapid proliferation, aggressive migration, and invasion into normal brain tissue. Formin proteins have been implicated in these processes. However, the role of formin-like 1 (FMNL1) in cancer remains unclear. We studied FMNL1 expression in glioblastoma samples using immunohistochemistry. We sought to analyze the correlation between FMNL1 expression, clinicopathologic variables, and patient survival. Migration and invasion assays were used to verify the e; ect of FMNL1 on glioblastoma cell lines. Microarray data were downloaded from The Cancer Genome Atlas and analyzed using gene set enrichment analysis (GSEA). FMNL1 was an independent predictor of poor prognosis in a cohort of 217 glioblastoma multiforme cases (p < 0.001). FMNL1 expression was significantly higher in the mesenchymal subtype. FMNL1 upregulation and downregulation were associated with mesenchymal and proneural markers in the GSEA, respectively. These data highlight the important role of FMNL1 in the neural-to-mesenchymal transition. Conversely, FMNL1 downregulation suppressed glioblastoma multiforme cell migration and invasion via DIAPH1 and GOLGA2, respectively. FMNL1 downregulation also suppressed actin fiber assembly, induced morphological changes, and diminished filamentous actin. FMNL1 is a promising therapeutic target and a useful biomarker for GBM progression. Nayuta Higa, Yoshinari Shinsato, Muhammad Kamil, Takuro Hirano, Tomoko Takajo , Michiko Shimokawa, Kentaro Minami, Masatatsu Yamamoto, Kohichi Kawahara, Hajime Yonezawa, Hirofumi Hirano, Tatsuhiko Furukawa, Koji Yoshimoto and Kazunori Arita Formin-like 1 (FMNL1) Is Associated with Glioblastoma Multiforme Mesenchymal Subtype and Independently Predicts Poor Prognosis International Journal of Molecular Sciences 2019, 20, 6355 https://doi.org/10.3390/ijms20246355
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 鹿児島大学 : 鹿児島大学リポジトリ

目次

Result_Higa_Nayuta_isk_550 other

Comments_Higa_Nayuta_isk_550 other

Diss_比嘉_那優大_ISK550_2019 fulltext

Abstract_比嘉_那優大_4516810183_2019 abstract