並列タイトル等Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity : A cross-sectional study
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Nonalcoholic fatty liver disease (NAFLD) is recognized as a hepatic manifestation of metabolic syndrome because of the association with visceral obesity. However, the association between NAFLD and subcutaneous fat accumulation remains unclear.
The study population included 3197 participants in regular health checkups, who were both hepatitis B virus surface antigen and hepatitisCvirus antibody-negative, andconsumed<20g of alcohol per day. Theyweredivided according to 4 quantiles of subcutaneous fat area (SFA) and visceral fat area (VFA) on computed tomography. Fatty liver was diagnosed using ultrasonography (FL-US).
The prevalence of FL-US increased across the SFA categories, even after adjusting for the VFA, in both men (P<.001) and women (P<.001). This significant association between FL-US and the SFA was already detected from the second SFA quantile. It is noteworthy that the mean body mass index (BMI) of the subjects in the second quantile was 23.7kg/m2 in men and 22.6kg/m2 in women. Independent positive associations were observed between alanine aminotransferase elevation, and both the SFA and VFA in men, while gamma glutamyl transpeptidase elevation was independently associated with the VFA, but not the SFA, in both men and women. Similarly, the components of metabolic syndrome were independently associated with the VFA, but were less strongly associated (or not associated at all) with the SFA.
This cross-sectional study suggests that NAFLD is independently associated with both visceral and subcutaneous adiposity ab initio, which is a characteristic that distinguishes NAFLD from other components of metabolic syndrome.
Takeshi Kure, Seiichi Mawatari, Yasushi Imamura, Kotaro Kumagai,Yasunari Hiramine, Hironori Miyahara, Shuji Kanmura, Akihiro Moriuchi, Hirofumi Uto, Masahisa Horiuchi
Nonalcoholic fatty liver disease is associated with both subcutaneous and visceral adiposity
Medicine, 2019 98(46) p.e17879
http://dx.doi.org/10.1097/MD.0000000000017879
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）