並列タイトル等Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti-inflammatory response
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
Dysbiosis of the enteric microbiota causes gastrointestinal diseases, including colitis. The present study investigated the beneficial effect of Lactobacillus plantarum 06CC 2 in experimental colitis in mice. An experimental colitis model in C57BL6 mice was induced using dextran sulfate sodium. Mice were orally administered 06CC 2 (06CC 2 group) or PBS only (control group) by gavage. The disease activity index (DAI ), histological grading, and colon tissue and colonic lamina propria mononuclear cells (LPMCs) were examined macroscopically and histopathologically, and the expression levels of inflammation‑associated cytokines (IL‑ 6, IL‑ 12, TNF‑α and IL‑ 10) in these samples were determined. Compared with the control group, the 06CC 2 group exhibited a significantly lower DAI (1.5±0.8 vs. 0.2±0.3, respectively; P<0.05) and pathology score (6.3±1.5 vs. 3.8±1.3, respectively; P<0.05). IL‑ 10 expression in colonic LPMCs was higher in the 06CC 2 group than in the control group, although there was no significant difference in IFN‑γ, IL‑ 6 or IL‑ 12 expression in colonic LPMCs between the two groups. In addition, 06CC 2 stimulated the production of IL‑ 10 from CD 11b‑positive cells and CD 11c‑positive cells in the colon. The 06CC 2 strain induced IL‑ 10 production in the colon and attenuated colon inflammation.
AKIHITO TANAKA, SHUJI KANMURA, YUKO MORINAGA, KATSUTO KAWABATA, SHIHO ARIMA, FUMISATO SASAKI, YUICHIROU NASU, SHIROH TANOUE, SHINICHI HASHIMOTO, MASAHIKO TAKESHITA, SHIRO TAKEDA and AKIO IDO
Oral administration of Lactobacillus plantarum 06CC2 prevents experimental colitis in mice via an anti‑inflammatory response
Molecular Medicine RE POR TS 21: 1181-1191, 2020
DOI : 10.3892/mmr.2020.10925
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）