並列タイトル等Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film
学位博士(歯学)
Doctor of Philosophy in Dental Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
The present study investigated the wound healing process in a rat skin wound model dressed with a hexanoyl group-modified alkaline-treated gelatin porous (HxAlGltn) film with angiogenesis-inducing and strong bioadhesive properties or a collagen sponge (CS). A circular 10-mm full-thickness skin defect was created on the backs of 8-week-old rats and then dressed with a HxAlGltn film (HxAlGltn group), collagen sponge (CS group), and no dressing (control group). Wound distances and areas were assessed macroscopically at specific time points after surgery, the lengths and thicknesses of the neo-epithelium histologically, and α-smooth muscle actin (α-SMA), collagen type I, and fibronectin immunohistochemically.
Wound distances and areas were significantly smaller in the HxAlGltn group than in the CS and control groups. The expression of α-SMA in myofibroblasts was significantly weaker in the HxAlGltn group than in the other groups on day 7. Furthermore, angiogenesis was prominent on days 4 and 7 in the HxAlGltn group. No significant differences were observed in the length of the neo-epithelium between all groups, whereas the thickness of the neo-epithelium was greater in the HxAlGltn group than in the CS group.
The present results suggest the potential of the HxAlGltn film as a dressing material in the wound healing process of full-thickness skin defects because it reduces scar contraction and promotes angiogenesis more than CS.
This is the peer reviewed version of the following article:
Takashi Koga, Toshiro Kibe, Tetsushi Taguchi, Takao Fuchigami, Kazuhide Nishihara, Kiyohide Ishihata, Norifumi Nakamura.
Evaluation of the wound healing process in rat skin using a hexanoyl group-modified alkaline-treated gelatin porous film
Oral Science International (2021), 18(1), 40-49
© 2020 Japanese Stomatological Society
which has been published in final form at https://doi.org/10.1002/osi2.1077
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連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）