並列タイトル等Dynamic changes in platelets caused by shear stress in aortic valve stenosis
学位博士(医学)
Doctor of Philosophy in Medical Science
一般注記博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨
BACKGROUND AND OBJECTIVE:
Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors.
METHODS:
We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital.
RESULTS:
Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen.
CONCLUSION:
Shear stress affects PLT count, PDW, and fibrinogen in patients with AS.
Kanda Hideaki, Yamakuchi Munekazu, Matsumoto Kazuhisa, Mukaihara Kosuke, Shigehisa Yoshiya, Tachioka Shuji, Okawa Masashi, Takenouchi Kazunori, Oyama Yoko, Hashiguchi Teruto, Imoto Yutaka
Dynamic changes in platelets caused by shear stress in aortic valve stenosis
Clinical Hemorheology and Microcirculation, 77(1), pp. 71-81, 2021
The final publication is available at IOS Press through https://doi.org/10.3233/CH-200928
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）