デジタルデータあり(広島大学学術情報リポジトリ)
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- 資料種別
- 文書・図像類
- 著者・編者
- Sada, NaotakaHanafusa, TakahiroOnizuka, YuichiHayashida, YasufumiKageyama, ShotaYamashita, Ichiro
- 著者標目
- 掲載ページ
- 1-26
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- type:textRetinoic acid (RA) has been shown to have a role in vascular formation, but how it affects is not fully understood. Previously, we reported that RA and its nuclear receptor (RAR) is required for transcription of ahr1 encoding an aryl hydrocarbon receptor (AHR), and that pharmacological modulation of RA, RAR, and AHR impairs the formation of common cardinal veins (CCVs) on the yolk of medakafish embryos. Here, to delineate a role for ahr1 in the vascular formation, we used an antisense-ahr1 mRNA to suppress ahr1. Following the development of vegfr1-expressing angioblast cells, we show that the antisense-ahr1 greatly inhibited the accumulation of angioblasts at the prospective branchial arch (PBA) where CCVs begin to develop on the yolk and the following CCV formation, demonstrating for the first time the essential role of ahr1 in the embryonic vascular formation of vertebrates. We also show that rarα and ahr1 mRNAs are co-expressed at PBA, suggesting a possible role of the specific expression.This work was supported in part by a grant from the Ministry of Education, Science, Sports and Culture of Japan.
- 記録形式(IMT)
- application/pdf