A model for how fission yeast cells scale their size with ploidy
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- 資料種別
- 文書・図像類
- 著者・編者
- Yamashita, Ichirou
- 掲載ページ
- 1-65
- 本文の言語コード
- eng
- 対象利用者
- 一般
- 一般注記
- type:textIt has long been known that eukaryotic cells with more DNA content are larger in cell size. However, no molecular mechanisms for this universal rule have been given. In the fission yeast Schizosaccharomyces pombe, diploid cells grow faster at 1.5-fold rate than haploid cells during the same cycle time. Here I discovered that cell division genes control not only cell growth or cell extension rate (CER) but also cycle time dose-dependently in diploid cells. These genes are well-known regulators for Cdc2, a conserved master regulator of eukaryotic cell cycle, such as inhibitors (wee1+ and pom1+) and activators (cdc25+ and nim1+). Actin content and its dynamics between monomer and polymer forms also control CER and cycle time through nuclear accumulation of Wee1 and Cdc25. Remarkably, doubling these genes in haploids reproduced CER of diploids. I propose a model in which regulatory cascades for Cdc2 activity govern the cell-size scaling with ploidy.
- 記録形式（IMT）
- application/pdf