Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats

• 資料種別: 博士論文
• タイトル: Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters intestinal vitamin A status in rats
• 著者・編者: 蛇口, 琢; HEBIGUCHI, Taku
• 著者標目: 蛇口, 琢; HEBIGUCHI, Taku
• 出版事項: 秋田大学
• 出版年月日等: 2015-11-01
• 出版年（W3CDTF）: 2015-11-01
• 並列タイトル等: 大量腸管切除にて腸管細胞内レチノール結合タンパク質 II およびアポリポ タンパク質 A-IV の遺伝子発現が上昇しラット腸管におけるビタミン A 環境 を変化させる
• 授与機関名: 秋田大学
• 授与年月日: 2015-09-24
• 報告番号: 甲第1142号
• 学位: 博士（医学）
• 本文の言語コード: jpn
• 対象利用者: 一般
• 一般注記: Short bowel (SB) syndrome causes the malabsorption of various nutrients. Among them, vitamin A is important for many physiological activities. Vitamin A is taken up by absorptive epithelial cells of the small intestine and discharged into lymphatics as a component of chylomicrons and delivered to the liver. Here, we used a rat model of SB syndrome to assess its effects on the expression of genes associated with the absorption, transport and metabolism of vitamin A. In SB rats, intestinal expression levels of mRNAs for cellular retinol-binding protein II (CRBP II, gene symbol Rbp2) and apolipoprotein A-IV (gene symbol Apoa4) were higher than in shams. Absorptive epithelial cells stained positively for both CRBP II and lecithin:retinol acyltransferase, both needed for effective esterification of vitamin A. In SB rats, the ileal retinol content and the jejunal retinyl esters content were lower than in sham rats. These results suggest that the elevated expression levels of Rbp2 and Apoa4 mRNAs in SB rats contribute to the effective esterification and transport of vitamin A.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.3892/ijmm.2015.2066
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 秋田大学 : 秋田大学学術情報リポジトリ

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