Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit 3

• 資料種別: 博士論文
• ISSN: 1347-8613
• タイトル: Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit
• 巻次・部編番号: 129 3
• 著者・編者: Kitamura, Yoshiaki; Nakagawa, Hideyuki; Fujii, Tatsuya; Sakoda, Takema; Enomoto, Tadao; Mizuguchi, Hiroyuki; Fukui, Hiroyuki; Takeda, Noriaki
• 著者標目: Kitamura, Yoshiaki; Nakagawa, Hideyuki; Fujii, Tatsuya; Sakoda, Takema; Enomoto, Tadao; Mizuguchi, Hiroyuki; Fukui, Hiroyuki; Takeda, Noriaki
• 出版事項: Japanese Pharmacological Society|Elsevier
• 出版年月日等: 2015-10-30
• 出版年（W3CDTF）: 2015-10-30
• 並列タイトル等: 花粉曝露室のスギ花粉曝露によりスギ花粉症患者に誘発された鼻粘膜ヒスタミンH1受容体mRNA発現亢進に対する抗ヒスタミン薬の影響
• タイトル（掲載誌）: Journal of Pharmacological Sciences
• 授与機関名: 徳島大学
• 授与年月日: 2016-03-22
• 授与年月日（W3CDTF）: 2016-03-22
• 報告番号: 甲第2953号
• 学位: 博士（医学）
• 博論授与番号: 甲第2953号
• 本文の言語コード: eng
• 件名標目: histamine H1 receptor; antihistamines; allergic rhinitis; cedar pollinosis; environmental exposure unit
• 対象利用者: 一般
• 一般注記: In the present study, we examined the effects of antihistamine on the up-regulation of H1R mRNA in the nasal mucosa of patients with pollinosis induced by controlled exposure to pollen using an environmental exposure unit. Out of 20 patients, we designated 14 responders, whose levels of H1R mRNA in the nasal mucosa were increased after the first pollen exposure and excluded 6 non-responders. Accordingly, the first exposure to pollen without treatment significantly induced both nasal symptoms and the upregulation of H1R mRNA in the nasal mucosa of the responders. Subsequently, prophylactic administration of antihistamine prior to the second pollen exposure significantly inhibited both of the above effects in the responders. Moreover, the nasal expression of H1R mRNA before the second pollen exposure in the responders pretreated with antihistamine was significantly decreased, as compared with that before the first pollen exposure without treatment. These findings suggest that antihistamines suppressed histamine-induced transcriptional activation of H1R gene in the nasal mucosa, in addition to their blocking effect against histamine on H1R, resulting in a decrease of nasal symptoms. These findings further suggest that by their inverse agonistic activity, antihistamines suppress the basal transcription of nasal H1R in the absence of histamine in responders.
• DOI: info:doi/10.1016/j.jphs.2015.10.007; https://doi.org/info:doi/10.1016/j.jphs.2015.10.007
• 国立国会図書館永続的識別子: info:ndljp/pid/10121344; https://dl.ndl.go.jp/pid/10121344
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2016-07-07T04:28:02+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://repo.lib.tokushima-u.ac.jp/109692
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp