並列タイトル等Disrupted Bone Metabolism in Long-Term Bedridden Patients
長期寝たきり患者における骨代謝障害
一般注記Background : Bedridden patients are at risk of osteoporosis and fractures, although the long-term bone metabolic processes in these patients are poorly understood. Therefore, we aimed to determine how long-term bed confinement affects bone metabolism.Methods : This study included 36 patients who had been bedridden from birth due to severe immobility.Bone mineral density and bone metabolism markers were compared to the bedridden period in all study patients. Changes in the bone metabolism markers during a follow-up of 12 years were studied in 17 patients aged <30 years at baseline.Results : \
The bone mineral density was reduced (0.58±0.19 g/cm3), and the osteocalcin (13.9±12.4ng/mL) and urine N-terminal telopeptide (NTX) levels (146.9±134.0 mM BCE/mM creatinine)were greater than the cutoff value for predicting fracture. Among the bone metabolism markers studied, osteocalcin and NTX were negatively associated with the bedridden period. During the follow-up, osteocalcin and parathyroid hormone were decreased, and the 25(OH) vitamin D was increased. NTX at baseline was negatively associated with bone mineral density after 12 years. Conclusions : Unique bone metabolic abnormalities were found in patients who had been bedridden for long periods, and these metabolic abnormalities were altered by further bed confinement.\
Appropriate treatment based on the unique bone metabolic changes may be important in long-term bedridden patients.
学位の種類: 博士（医学）. 報告番号: 甲第4213号. 学位記番号: 新大院博（医）甲第712号. 学位授与年月日: 平成28年9月20日
PLoS ONE 11(6): e0156991
新大院博（医）甲第712号
DOIinfo:doi/10.1371/journal.pone.0156991
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