Maxillofacial bone regeneration with osteogenic matrix cell sheets: An experimental study in rats.

• 資料種別: 博士論文
• ISSN: 0003-9969
• タイトル: Maxillofacial bone regeneration with osteogenic matrix cell sheets: An experimental study in rats.
• 巻次・部編番号: 72
• 著者・編者: Ueyama, Yoshihiro; Yagyuu, Takahiro; Maeda, Masahiko; Imada, Mitsuhiko; Akahane, Manabu; Kawate, Kenji; Tanaka, Yasuhito; Kirita, Tadaaki
• 著者標目: Ueyama, Yoshihiro; Yagyuu, Takahiro; Maeda, Masahiko; Imada, Mitsuhiko; Akahane, Manabu; Kawate, Kenji; Tanaka, Yasuhito; Kirita, Tadaaki
• 出版事項: Elsevier
• 出版年月日等: 2016-12; 72
• 出版年（W3CDTF）: 2016-12
• 並列タイトル等: 骨形成シートによる顎顔面の再生 : ラットにおける実験研究
• タイトル（掲載誌）: Archives of oral biology Vol. p.
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2017-03-15
• 授与年月日（W3CDTF）: 2017-03-15
• 報告番号: 甲第668号
• 学位: 博士（医学）
• 博論授与番号: 甲第668号
• 本文の言語コード: eng
• 件名標目: Bone regeneration; Mandibular defect; Bone marrow-derived stromal cells; Cell sheet
• 対象利用者: 一般
• 一般注記: type:Thesis; OBJECTIVE: Regeneration of maxillofacial bone defects, characterized by relatively small but complicated shapes, poses a significant clinical challenge. Osteogenic matrix cell sheets (OMCSs) have osteogenic ability and good shaping properties and may be ideal graft materials. Here, we assessed whether implantation of OMCSs could be used to repair maxillofacial bone defects. DESIGN: We adopted a rat mandibular symphysis model. The rat mandible is formed by a paired bone and the central portion consisting of fibrous tissue. There is no bone tissue at the site; accordingly, this site was interpreted as a physiological bone gap and was used for evaluation. Rat bone marrow cells were cultured in medium containing dexamethasone and ascorbic acid phosphate to create OMCSs. The OMCSs were implanted into the rat mandibular symphysis without a scaffold. Microcomputed tomography and histological analyses were conducted after 2, 4, and 8 weeks. RESULTS: Two weeks after implantation, microcomputed tomography images and histological sections showed some sparse granular calcification tissue within the bone gap at the mandibular symphysis. At 4 weeks, the calcification tissue spread, and the gap of the mandibles were continued. At 8 weeks, this continuous new bone tissue was matured. The experimental group showed abundant new bone tissue in the group with OMCS implantation, but not in the group with sham implantation. CONCLUSIONS: Our present results indicated that use of OMCSs may be an optimal approach towards achieving maxillofacial regeneration.; 博士（医学）・甲第668号・平成29年3月15日; Copyright © 2016 Elsevier Ltd. All rights reserved.; identifier:Archives of oral biology Vol.72 p.138-145 (2016 Dec); identifier:00039969; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3321; identifier:Archives of oral biology Vol. p., 72: 138-145
• DOI: info:doi/10.1016/j.archoralbio.2016.08.017; https://doi.org/info:doi/10.1016/j.archoralbio.2016.08.017
• 国立国会図書館永続的識別子: info:ndljp/pid/10342512; https://dl.ndl.go.jp/pid/10342512
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-05-02T23:17:13+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10564/3321
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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