Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model

• 資料種別: 博士論文
• ISSN: 1742-7061
• タイトル: Diversity of multinucleated giant cells by microstructures of hydroxyapatite and plasma components in extraskeletal implantation model
• 巻次・部編番号: 39
• 著者・編者: 森下, 廣太
• 著者標目: 森下, 廣太
• 出版事項: Elsevier Ltd.
• 出版年月日等: 2017-03-21
• 出版年（W3CDTF）: 2017-03-21
• 並列タイトル等: 皮下移植実験系においてハイドロキシアパタイトの微細構造及び血漿成分の影響を受けて誘導される多様な多核巨細胞
• タイトル（掲載誌）: Acta Biomaterialia
• 授与機関名: Nagasaki University (長崎大学)
• 授与年月日: 2017-03-21
• 授与年月日（W3CDTF）: 2017-03-21
• 報告番号: 甲医歯薬第923号
• 学位: 博士(歯学)
• 博論授与番号: 甲医歯薬第923号
• 本文の言語コード: eng
• 件名標目: Foreign body giant cell; Osteoclast; Hydroxyapatite; Microstructure; Cathepsin K
• 対象利用者: 一般
• 一般注記: Foreign body giant cells (FBGCs) and osteoclasts are multinucleated giant cells (MNGCs), both of which are formed by the fusion of macrophage-derived mononuclear cells. Osteoclasts are distinct from FBGCs due to their bone resorption ability; however, not only morphological, but also functional similarities may exist between these cells. The characterization and diversity of FBGCs that appear in an in vivo foreign body reaction currently remain incomplete. In the present study, we investigated an in vivo foreign body reaction using an extraskeletal implantation model of hydroxyapatite (HA) with different microstructures. The implantation of HA granules in rat subcutaneous tissue induced a foreign body reaction that was accompanied by various MNGCs. HA granules composed of rod-shaped particles predominantly induced cathepsin K (CTSK)-positive FBGCs, whereas HA granules composed of globular-shaped particles predominantly induced CTSK-negative FBGCs. Plasma, which was used as the binder of ceramic granules, stimulated the induction of CTSK-positive FBGCs more strongly than purified fibrin. Furthermore, the implantation of HA composed of rod-shaped particles with plasma induced tartrate-resistant acid phosphatase (TRAP)-positive MNGCs in contrast to HA composed of globular-shaped particles with purified fibrin, which predominantly induced CTSK-negative and TRAP-negative typical FBGCs. These results suggest that CTSK-positive, TRAP-positive, and CTSK- and TRAP-negative MNGCs are induced in this subcutaneous implantation model in a manner that is dependent on the microstructure of HA and presence or absence of plasma.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第923号 学位授与年月日:平成29年3月21日; Author: Kota Morishita, Eri Tatsukawa, Yasuaki Shibata, Fumio Suehiro, Masanobu Kamitakahara, Taishi Yokoi, Koji Ioku, Masahiro Umeda, Masahiro Nishimura, Tohru Ikeda; Citation: Acta Biomaterialia, 39, pp.180-191; 2016; Nagasaki University (長崎大学), 博士(歯学) (2017-03-21)
• DOI: info:doi/10.1016/j.actbio.2016.05.002; https://doi.org/info:doi/10.1016/j.actbio.2016.05.002
• 国立国会図書館永続的識別子: info:ndljp/pid/10342621; https://dl.ndl.go.jp/pid/10342621
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-05-02T23:17:13+09:00
• 作成日（W3CDTF）: 2020-12-21
• 記録形式（IMT）: PDF
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10069/37099; https://nagasaki-u.repo.nii.ac.jp/records/3908
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

目次

2021-03-07 再収集