Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model

• 資料種別: 博士論文
• ISSN: 1559-7016
• タイトル: Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model
• 巻次・部編番号: 37 8
• 著者・編者: Miyamoto, Takeshi; Kung, David K.; Kitazato, Keiko T.; Yagi, Kenji; Shimada, Kenji; Tada, Yoshiteru; Korai, Masaaki; Kurashiki, Yoshitaka; Kinouchi, Tomoya; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji
• 著者標目: Miyamoto, Takeshi; Kung, David K.; Kitazato, Keiko T.; Yagi, Kenji; Shimada, Kenji; Tada, Yoshiteru; Korai, Masaaki; Kurashiki, Yoshitaka; Kinouchi, Tomoya; Kanematsu, Yasuhisa; Satomi, Junichiro; Hashimoto, Tomoki; Nagahiro, Shinji
• 出版事項: International Society for Cerebral Blood Flow and Metabolism|Sage
• 出版年月日等: 2016-01-01
• 出版年（W3CDTF）: 2016-01-01
• 並列タイトル等: 新規脳動脈瘤ラットモデルにおける血行力学的変化によるウィリス動脈輪内の部位特異的なIL-1βとMMP-9の上昇は破裂に関連する; Rupture related to site-specific MMP-9 elevation
• タイトル（掲載誌）: Journal of Cerebral Blood Flow & Metabolism
• 授与機関名: 徳島大学
• 授与年月日: 2017-03-23
• 授与年月日（W3CDTF）: 2017-03-23
• 報告番号: 甲第3005号
• 学位: 博士（医学）
• 博論授与番号: 甲第3005号
• 本文の言語コード: eng
• 件名標目: Animal Models; Cerebral Hemodynamics; Inflammation; Intracranial Aneurysm; Subarachnoid Hemorrhage
• 対象利用者: 一般
• 一般注記: The pathogenesis of subarachnoid hemorrhage (SAH)remains unclear. No models of cerebral aneurysms elicited solely by surgical procedures and diet have been established.Elsewhere we reported that only few rats in our original rat aneurysm model manifested rupture at the anterior-and posterior Willis circle (AW, PW) and thatmany harbored unruptured aneurysms at the anterior cerebral artery-olfactory artery bifurcation (ACA-OA). This suggests that rupture was site-specific. To test our hypothesis that a site-specific responseto hemodynamic changes is associated with aneurysmal rupture, we modified our original aneurysm model by altering the hemodynamics. During 90-day observation, the incidenceof ruptured aneurysms at the AW and PWwas significantly increasedand the high incidence of unruptured aneurysms at the ACA-OA persisted. This phenomenon was associatedwith an increase in the blood flow volume (BFVo). Notably, the level of matrix metalloproteinase(MMP)-9 associated with interleukin (IL)-1βwas augmented by the increase in the BFVo, suggesting that these molecules exacerbated the vulnerability of the aneurysmal wall. The current study first demonstrates that a site-specificincrease in IL-1β and MMP-9 elicited by hemodynamic changes is associated with rupture. Our novel rat model of rupture may help to developpharmaceutical approaches to prevent rupture.
• DOI: info:doi/10.1177/0271678X16675369; https://doi.org/info:doi/10.1177/0271678X16675369
• 国立国会図書館永続的識別子: info:ndljp/pid/10342773; https://dl.ndl.go.jp/pid/10342773
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-05-02T23:17:13+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://repo.lib.tokushima-u.ac.jp/110032
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp