Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS)

• 資料種別: 博士論文
• タイトル: Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS)
• 著者・編者: Matsunaga, Satoshi
• 出版事項: 新潟大学
• 出版年月日等: 2017-09-20
• 出版年（W3CDTF）: 2017-09-20
• 並列タイトル等: Association between all-cause mortality and severity of depressive symptoms in patients with type 2 diabetes : analysis from the Japan Diabetes Complications Study (JDCS); 2型糖尿病患者におけるうつ症状重症度と全死因死亡の関係に関する検討
• 授与機関名: 新潟大学
• 授与年月日: 2017-09-20
• 授与年月日（W3CDTF）: 2017-09-20
• 報告番号: 甲第4361号
• 学位: 博士（医学）
• 博論授与番号: 甲第4361号
• 本文の言語コード: eng
• 件名標目: Diabetes mellitus, type 2; Depressive disorder; Death; Hypoglycemia
• 一般注記: Objective: The aims of this study are to confirm whether the excess mortality caused by depressive symptoms is independent of severe hypoglycemia in patients with type 2 diabetes mellitus (T2DM) and to evaluate the association between all-cause mortality and degrees of severity of depressive symptoms in Japanese patients with T2DM. Methods: A total of 1160 Japanese patients with T2DM were eligible for this analysis. Participants were followed prospectively for 3 years and their depressive states were evaluated at baseline by the Center for Epidemiologic Studies Depression Scale (CES-D). Cox proportional hazards model was used to evaluate the relative risk of allcause mortality and was adjusted by possible confounding factors, including severe hypoglycemia, all of which are known as risk factors for both depression and mortality. Results: After adjustment for severe hypoglycemia, each 5-point increase in the CES-D score was significantly associated with excess all-cause mortality (hazard ratio 1.69 [95% CI 1.26.2.17]). The spline curve of HRs for mortality according to total CES-D scores showed that mortality risk was slightly increased at lower scores but was sharply elevated at higher scores. Conclusion: A high score on the CES-D at baseline was significantly associated with all-cause mortality in patients with T2DM after adjusting for confounders including severe hypoglycemia. However, only a small effect on mortality risk was found at relatively lower levels of depressive symptoms in this population. Further research is needed to confirm this relationship between the severity of depressive symptoms and mortality in patients with T2DM.; 学位の種類: 博士（医学）. 報告番号: 甲第4361号. 学位記番号: 新大院博（医）甲第774号. 学位授与年月日: 平成29年9月20日; Journal of Psychosomatic Research. 2017, 99, 34–39.; 新大院博（医）甲第774号; 元資料の権利情報 : (C) 2017 Elsevier Inc. All rights reserved.
• DOI: info:doi/10.1016/j.jpsychores.2017.05.020; https://doi.org/info:doi/10.1016/j.jpsychores.2017.05.020
• 国立国会図書館永続的識別子: info:ndljp/pid/10993758; https://dl.ndl.go.jp/pid/10993758
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-12-04T02:02:48+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/48150
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp