Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring

• 資料種別: 博士論文
• タイトル: Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring
• 著者・編者: Yata, Yusuke
• 出版事項: 新潟大学
• 出版年月日等: 2017-09-20
• 出版年（W3CDTF）: 2017-09-20
• 並列タイトル等: Efficacy of dipeptidyl peptidase-4 inhibitors in patients with glucocorticoid-induced diabetes assessed by continuous glucose monitoring; 持続血糖モニタリングを用いた糖質コルチコイド起因性糖尿病患者へのDipeptidyl peptidase-4阻害薬の効果の検討
• 授与機関名: 新潟大学
• 授与年月日: 2017-09-20
• 授与年月日（W3CDTF）: 2017-09-20
• 報告番号: 甲第4355号
• 学位: 博士（医学）
• 博論授与番号: 甲第4355号
• 本文の言語コード: eng
• 件名標目: dipeptidyl peptidase-4 inhibitor; glucocorticoid-induced diabetes; continuous glucose monitoring
• 一般注記: Objective Administration of glucocorticoids usually causes a mild increase in fasting glucose levels and a greater dose-dependent increase in postprandial values in patients without pre-existing diabetes mellitus. Patients with persistent hyperglycemia due to glucocorticoid therapy sometimes require insulin therapy that may result in more weight gain and more episodes of hypoglycemia, some of which are severe. On the other hand, scant evidence is available on the efficacy of oral hypoglycemic agents for glucocorticoid-induced diabetes. In this study, we evaluated the efficacy of dipeptidyl peptidase (DPP)-4 inhibitors in patients with glucocorticoid-induced diabetes by continuous glucose monitoring (CGM). Methods We examined glycemic profiles using CGM at baseline and 1–4 weeks after initiating DPP-4 inhibitor treatment in patients with newly developed glucocorticoid-induced diabetes. Results Eleven patients diagnosed with kidney disease or other diseases with renal involvement were recruited for retrospective analysis in this study. After starting DPP-4 inhibitors, the mean and the SD of glucose levels, and the mean amplitude of glycemic excursion (MAGE) were significantly improved compared with baseline. Furthermore, the area over the curve for glucose levels <70 mg/dL was not increased compared with baseline after initiating DPP-4 inhibitors. Treatment of patients with glucocorticoid-induced diabetes using DPP-4 inhibitors can thus minimize the risk of hypoglycemia and reduce glucose variability. Conclusion DPP-4 inhibitors are potentially useful for blood glucose control in patients with glucocorticoid-induced diabetes.; 学位の種類: 博士（医学）. 報告番号: 甲第4355号. 学位記番号: 新大院博（医）甲第768号. 学位授与年月日: 平成29年9月20日; The Assessment of the Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Glucocorticoid-induced Diabetes by Continuous Glucose Monitoring. Internal Medicine. 2017, 56(19), 2555-2562.; 新大院博（医）甲第768号; 元資料の権利情報 : (C) 2017 by The Japanese Society of Internal Medicine; 開始ページ : 1; 終了ページ : 24
• DOI: info:doi/10.2169/internalmedicine.8296-16; https://doi.org/info:doi/10.2169/internalmedicine.8296-16
• 国立国会図書館永続的識別子: info:ndljp/pid/10993765; https://dl.ndl.go.jp/pid/10993765
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2017-12-04T02:02:48+09:00
• 作成日（W3CDTF）: 2019-08-05
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: http://hdl.handle.net/10191/48159
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp