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Objective: To investigate the effect of a novel topical wound-healing agent, low-concentration povidone-iodine ointment (LPIO) with a hydrophobic white petrolatum-rich base, on skin-wound models in rats and rabbits. Methods: We investigated the therapeutic efficacy of topically applied LPIO compared to that of standard-concentration povidone-iodine ointment (SPIO) and non-treatment control, using a full-thickness skin-wound model in hairless rats and a full-thickness skin-defect model in rabbit earlobes. Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations. Results: LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO. Conclusions: The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.
本文 / Central Research Laboratory, Maruishi Pharmaceutical Co., Ltd.; Department of Dermatology, Mie University Graduate School of Medicine
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DOIinfo:doi/10.12968/jowc.2016.25.9.521
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