(Pro)renin and (pro)renin receptor expression during kidney development in neonates

• 資料種別: 博士論文
• ISSN: 0340-6199
• タイトル: (Pro)renin and (pro)renin receptor expression during kidney development in neonates
• 巻次・部編番号: 176 2
• 著者・編者: Terada, Tomomasa; Urushihara, Maki; Saijo, Takahiko; Nakagawa, Ryuji; Kagami, Shoji
• 著者標目: Terada, Tomomasa; Urushihara, Maki; Saijo, Takahiko; Nakagawa, Ryuji; Kagami, Shoji
• 出版事項: Springer Berlin Heidelberg
• 出版年月日等: 2016-12-19
• 出版年（W3CDTF）: 2016-12-19
• 並列タイトル等: 腎発生におけるプロレニン、プロレニン受容体の役割検討; Soluble (pro)renin receptor in neonates
• タイトル（掲載誌）: European Journal of Pediatrics
• 授与機関名: 徳島大学
• 授与年月日: 2017-03-23
• 授与年月日（W3CDTF）: 2017-03-23
• 報告番号: 甲第3013号
• 学位: 博士（医学）
• 博論授与番号: 甲第3013号
• 本文の言語コード: eng
• 件名標目: Renin-angiotensin; Gestational age; Cord blood; Enzyme-linked immunosorbent assay; Immunohistochemistry
• 対象利用者: 一般
• 一般注記: Although a recent study demonstrated that the (pro)renin receptor ((P)RR) was highly expressed in the developing kidney during the mouse embryonic development, the mechanism by which (P)RR supports renal development in humans is not fully understood. In this study, we examined the plasma levels of (pro)renin and soluble (P)RR (s(P)RR) in cord blood and neonates as well as (P)RR expression in human kidney tissues. Samples were collected from 57 preterm and 67 full-term human neonates. (Pro)renin and s(P)RR levels were measured using enzyme-linked immunosorbent assays. Additionally, we performed an immunohistochemical (IHC) analysis of kidney tissues from neonates and minor glomerular abnormalities in order to assess (P)RR expression in the kidney. Plasma (pro)renin and s(P)RR levels in cord blood were significantly higher in preterm neonates than in full-term neonates. Four weeks after birth, these differences were no longer evident for either plasma (pro)renin or s(P)RR levels between the two groups. Importantly, plasma (pro)renin and s(P)RR levels in cord blood were inversely correlated with gestational age. Furthermore, IHC indicated that renal expression levels of (P)RR in neonates was stronger than that in minor glomerular abnormalities.Conclusion: (P)RR may play a pivotal role in prenatal renal development in humans.
• DOI: info:doi/10.1007/s00431-016-2820-9; https://doi.org/info:doi/10.1007/s00431-016-2820-9
• 国立国会図書館永続的識別子: info:ndljp/pid/11008588; https://dl.ndl.go.jp/pid/11008588
• コレクション（共通）: 障害者向け資料
• コレクション（障害者向け資料：レベル1）: テキストデータ
• コレクション（個別）: 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• 収集根拠: 博士論文（自動収集）
• 受理日（W3CDTF）: 2018-01-02T17:18:43+09:00
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: 国立国会図書館内限定公開
• デジタル化資料送信: 図書館・個人送信対象外
• 遠隔複写可否（NDL）: 可
• 掲載誌（URI）: https://repo.lib.tokushima-u.ac.jp/110037
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp