並列タイトル等大腸癌肝転移におけるThrombospondin-1発現の役割とその分子メカニズム
タイトル（掲載誌）Journal of Hepato-Biliary-Pancreatic Sciences
一般注記Background/PurposeThrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial–mesenchymal transition (EMT), and expression of other relevant molecules.MethodsNinety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n=35] and THBS-1 low [n=59]) and tumor growth, Ki-67 labelling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated.ResultsTHBS1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS1 expression (3-year survival: 96.7% vs. 65.4%, p<0.01). Multivariate analysis identified THBS1 low expression as an independent prognostic factor (HR=2.82, 95% CI=1.21–7.71, p=0.01). THBS-1 low expression correlated positively with high Ki-67 LI (p<0.05) and inversely with E-cadherin (p<0.05) and hypoxia inducible factor-1α (HIF-1α) expression (p<0.05); THBS-1 expression and MVD were not significantly correlated.ConclusionsLow THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway.
DOIinfo:doi/10.1002/jhbp.376
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